US 12,214,298 B2
Systems and method for detection of analytes in high volumetric flow applications
Richard C. Willson, Houston, TX (US); Ujwal Patil, Houston, TX (US); Binh V. Vu, Houston, TX (US); Ekaterini Kourentzi, Houston, TX (US); and Mary Crum, Houston, TX (US)
Assigned to University of Houston System, Houston, TX (US)
Appl. No. 17/048,779
Filed by University of Houston System, Houston, TX (US)
PCT Filed Apr. 17, 2019, PCT No. PCT/US2019/027965
§ 371(c)(1), (2) Date Oct. 19, 2020,
PCT Pub. No. WO2019/204508, PCT Pub. Date Oct. 24, 2019.
Claims priority of provisional application 62/659,461, filed on Apr. 18, 2018.
Prior Publication US 2021/0178290 A1, Jun. 17, 2021
Int. Cl. B01D 15/38 (2006.01); G01N 27/00 (2006.01); G01N 30/88 (2006.01)
CPC B01D 15/3885 (2013.01) [B01D 15/388 (2013.01); G01N 27/00 (2013.01); G01N 2030/8831 (2013.01)] 32 Claims
OG exemplary drawing
 
1. A method of detecting the presence of a target analyte comprising
(a) contacting a sample or a separated portion of said sample with a reporter reagent that produces an optically or electromagnetically detectable signal in the presence of the target analyte; and
(b) determining the presence of said target analyte in said sample or said separated portion of said sample by measuring the optically or electromagnetically detectable signal, thereby detecting the presence of said target analyte, wherein
(i) the sample is a first liquid stream is derived from a primary flow stream resulting from a separative process, or
(ii) wherein the sample is formed from a separative process selected from the group consisting of chromatography, filtration/ultrafiltration, and precipitation/ZnCl2 precipitation.