US 12,214,297 B2
Regulated method for separating a mixture
Cédric Prieur, Genas (FR); and Eric Valéry, Saulxures-les-Nancy (FR)
Assigned to Novasep Process Solutions, Saint-Maurice-de-Beynost (FR)
Filed by Novasep Process Solutions, Saint-Maurice-de-Beynost (FR)
Filed on Nov. 14, 2023, as Appl. No. 18/509,100.
Application 18/509,100 is a continuation of application No. 16/762,457, granted, now 11,857,892, previously published as PCT/FR2018/052871, filed on Nov. 16, 2018.
Claims priority of application No. 1760830 (FR), filed on Nov. 16, 2017.
Prior Publication US 2024/0082752 A1, Mar. 14, 2024
Int. Cl. B01D 15/00 (2006.01); B01D 15/18 (2006.01); C13K 1/04 (2006.01); C13K 11/00 (2006.01)
CPC B01D 15/1828 (2013.01) [B01D 15/185 (2013.01); C13K 1/04 (2013.01); C13K 11/00 (2013.01); B01D 2215/024 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of separating a mixture in an installation comprising:
a first system comprising a plurality of chromatography columns, an outlet line for collecting a raffinate and an outlet line for collecting an extract;
at least one second system placed downstream of the first system; and
at least one tank fed by one of said outlet lines of the first system and feeding the second system with a continuous stream;
the method successively comprising, in a cyclic manner, in a given part of the first system:
a step of collecting a raffinate, a step of injecting the mixture to be separated, a step of collecting an extract, and a step of injecting a mobile phase;
wherein the method further comprises the measurement of the purity and/or of the yield of at least one collected fraction chosen from the extract and the raffinate, said measurement of the purity and/or of the yield comprising the following steps:
the determination of the concentration of at least two species of the mixture to be separated in the fraction collected in the tank;
the determination of the purity and/or of the yield of at least one species of the fraction collected in the tank.