US 12,214,219 B2
Systems and methods for biological adaptive radiotherapy
Michael Kirk Owens, San Francisco, CA (US); Rostem Bassalow, Hayward, CA (US); Peter Demetri Olcott, Los Gatos, CA (US); Yevgen Voronenko, Sunnyvale, CA (US); David Quentin Larkin, Menlo Park, CA (US); and Samuel Mazin, Menlo Park, CA (US)
Assigned to RefleXion Medical, Inc., Hayward, CA (US)
Filed by RefleXion Medical, Inc., Hayward, CA (US)
Filed on Apr. 4, 2023, as Appl. No. 18/295,448.
Application 18/295,448 is a continuation of application No. 16/016,272, filed on Jun. 22, 2018, granted, now 11,648,418.
Claims priority of provisional application 62/523,691, filed on Jun. 22, 2017.
Prior Publication US 2023/0390580 A1, Dec. 7, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 5/10 (2006.01); A61B 6/00 (2024.01); A61B 6/03 (2006.01)
CPC A61N 5/1031 (2013.01) [A61B 6/037 (2013.01); A61B 6/5217 (2013.01); A61N 5/1039 (2013.01); A61N 5/1049 (2013.01); A61N 5/1064 (2013.01); A61N 5/1067 (2013.01); A61N 5/1068 (2013.01); A61N 5/1071 (2013.01); A61N 2005/1034 (2013.01); A61N 5/1036 (2013.01); A61N 5/1037 (2013.01); A61N 5/1038 (2013.01); A61N 5/1045 (2013.01); A61N 2005/1052 (2013.01); A61N 2005/1055 (2013.01); A61N 2005/1058 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A method for calculating bounded dose-volume histograms (DVH) for evaluating a treatment plan, the method comprising:
generating a plurality of images X′1, 2, 3, . . . j based on an acquired patient image X, where a patient target volume (PTV) is located at j different positions within a radiation-firing zone (RFZ) of a patient;
calculating a dose Dj for each of the images X′1, 2, 3, . . . j by multiplying a dose calculation matrix A with a radiation-firing matrix P and X′j (Dj=A·P·Xj′);
plotting a dose-volume histogram (DVH) curve for each dose Dj to generate a family of j DVH curves, wherein the DVH curve for each dose Dj represents a volume fraction for each dose value; and
generating a minimum boundary curve (min-DVH curve) and a maximum boundary curve (max-DVH curve) of the family of DVH curves, wherein the min-DVH curve comprises a first series of points that represent a minimum volume fraction for each dose value of the family of DVH curves, and the max-DVH curve comprises a second series of points that represent a maximum volume fraction for each dose value.