US 12,214,218 B2
Perfusion modulated tumor dose sculpting with single dose radiotherapy
Richard Kolesnick, New York, NY (US); Zvi Fuks, New York, NY (US); and Carlo Greco, Lisbon (PT)
Assigned to MEMORIAL SLOAN KETTERING CANCER CENTER, New York, NY (US); and FUNDAçÃO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD, Lisbon (PT)
Appl. No. 17/631,152
Filed by MEMORIAL SLOAN KETTERING CANCER CENTER, New York, NY (US); and FUNDAçÃO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD, Lisbon (PT)
PCT Filed Jul. 30, 2020, PCT No. PCT/PT2020/050027
§ 371(c)(1), (2) Date Jan. 28, 2022,
PCT Pub. No. WO2021/020979, PCT Pub. Date Feb. 4, 2021.
Claims priority of provisional application 62/883,074, filed on Aug. 5, 2019.
Claims priority of provisional application 62/883,078, filed on Aug. 5, 2019.
Claims priority of provisional application 62/880,797, filed on Jul. 31, 2019.
Prior Publication US 2022/0296926 A1, Sep. 22, 2022
Int. Cl. A61N 5/10 (2006.01); A61K 41/00 (2020.01)
CPC A61N 5/1031 (2013.01) [A61K 41/0038 (2013.01); A61N 2005/1087 (2013.01); A61N 2005/1098 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of treating a tumor in a subject in need thereof, said tumor comprising:
a total planning target volume (PTVTOTAL) comprising the tumor's total volume, wherein the PTVTOTAL comprises a first planning target sub-volume (PTVHD) and a second planning target sub-volume (PTVPMDS), wherein the PTVPMDS comprises at least 5% of the tumor's total volume;
wherein the method comprises delivering a radiation dose to each of the PTVPMDS and PTVHD, wherein the dose of radiation delivered to the PTVPMDS is lower than the dose of radiation delivered to the PTVHD, and
wherein the dose of radiation delivered to the PTVPMDS is insufficient to treat the tumor when delivered to the entirety of the PTVTOTAL, optionally wherein:
the method reduces incidence of local relapse compared to fractionated radiotherapy methods, or
the tumor is adjacent to a dose limiting organ at risk (OAR), optionally wherein the OAR is a serial OAR, or
the radiation is delivered from a radiation source comprising a radioactive element selected from the group consisting of radioactive cesium, iridium, iodine, cobalt, and combinations thereof, or
the radiation is delivered from a radiation source selected from the group consisting of an x-ray emitter, an electron beam emitter, a proton beam emitter, and a linear accelerator.