US 12,214,199 B2
Treatment for loss of control disorders
Casey Halpern, Menlo Park, CA (US); Robert C. Malenka, Palo Alto, CA (US); and Hemmings Wu, Palo Alto, CA (US)
Assigned to THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, Palo Alto, CA (US)
Filed by The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US)
Filed on Mar. 22, 2023, as Appl. No. 18/188,120.
Application 18/188,120 is a continuation of application No. 16/337,315, granted, now 11,642,528, previously published as PCT/US2017/053820, filed on Sep. 27, 2017.
Claims priority of provisional application 62/400,483, filed on Sep. 27, 2016.
Prior Publication US 2024/0042206 A1, Feb. 8, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/36 (2006.01); A61B 5/00 (2006.01); A61N 1/05 (2006.01)
CPC A61N 1/36085 (2013.01) [A61B 5/4064 (2013.01); A61N 1/05 (2013.01); A61N 1/0529 (2013.01); A61N 1/36089 (2013.01); A61N 1/36139 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A method of detecting an anticipatory biomarker in the form of a low frequency modulation in a nucleus accumbens of a subject in need thereof, wherein the subject in need is one diagnosed with, or suspected of having, a loss of control or impulse control disorder and wherein the subject in need has at least one electrode inserted into their nucleus accumbens, the method comprising:
recording brain wave activity in a frequency range of from 0-38 hertz in the nucleus accumbens of the subject and in the absence of electrical stimulation administered to the brain; and
detecting a change in power compared to a baseline in a delta band corresponding to a frequency of from 1-4 Hz,
wherein detection of an increase in power in the delta band indicates detection of the anticipatory biomarker in the form of a low frequency modulation, wherein said low frequency modulation precedes the onset of a disorder symptom manifestation, wherein the method further comprises preventing the onset by administering, in response to detecting the anticipatory biomarker, an electrical stimulation to the nucleus accumbens of the subject.