US 12,214,196 B2
Systems and methods for treatment of cancer using alternating electric field generation
Benjamin Hendricks, San Francisco, CA (US); and Kris Smith, San Francisco, CA (US)
Assigned to Dignity Health, San Francisco, CA (US)
Filed by Dignity Health, San Francisco, CA (US)
Filed on Jan. 18, 2023, as Appl. No. 18/155,849.
Application 18/155,849 is a continuation of application No. 17/260,019, granted, now 11,565,111, previously published as PCT/US2019/042197, filed on Jul. 17, 2019.
Claims priority of provisional application 62/699,146, filed on Jul. 17, 2018.
Prior Publication US 2023/0149713 A1, May 18, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01); A61N 1/372 (2006.01); A61N 1/40 (2006.01)
CPC A61N 1/3606 (2013.01) [A61N 1/0531 (2013.01); A61N 1/0534 (2013.01); A61N 1/36139 (2013.01); A61N 1/37211 (2013.01); A61N 1/37235 (2013.01); A61N 1/40 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for the treatment of brain cancer, comprising:
an alternating electric field generation apparatus, comprising:
an electrode array, comprising:
a plurality of subdural electrodes, wherein each of the subdural electrodes is implantable subdurally onto the brain of a patient;
a plurality of deep-stimulating electrodes, wherein each of the plurality of deep-stimulating electrodes is implantable within the brain of the patient;
wherein the electrode array delivers an alternating electric field to the tissue of the brain through the plurality of subdural electrodes and the plurality of deep-stimulating electrodes; and
a processor in communication with a waveform generator and a memory, the waveform generator being in operative communication with the electrode array and the memory including instructions which, when executed, cause the processor to:
apply, by the waveform generator and at the electrode array, a waveform representative of the alternating electric field and configured for the treatment of brain cancer;
receive feedback from the electrode array following application of the waveform at the electrode array; and
determine a set of parameters of the waveform applied by the waveform generator and at the electrode array based on the feedback received from the electrode array.