US 12,214,189 B2
Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies
Melvin F. Lorenzo, Blacksburg, VA (US); Christopher B. Arena, Burlington, NC (US); Suyashree Bhonsle, Menlo Park, CA (US); Natalie White, Christiansburg, VA (US); Lucy Epshteyn, Blacksburg, VA (US); and Rafael V. Davalos, Blacksburg, VA (US)
Assigned to Virginia Tech Intellectual Properties, Inc., Blacksburg, VA (US); and Angio Dynamics, Inc., Latham, NY (US)
Filed by Virginia Tech Intellectual Properties, Inc., Blacksburg, VA (US); and Angio Dynamics, Inc., Latham, NY (US)
Filed on Jul. 24, 2020, as Appl. No. 16/938,778.
Claims priority of provisional application 62/895,652, filed on Sep. 4, 2019.
Claims priority of provisional application 62/878,194, filed on Jul. 24, 2019.
Prior Publication US 2021/0023362 A1, Jan. 28, 2021
Int. Cl. A61B 18/12 (2006.01); A61N 1/08 (2006.01); A61N 1/32 (2006.01); A61B 17/00 (2006.01); A61B 18/00 (2006.01)
CPC A61N 1/08 (2013.01) [A61B 18/12 (2013.01); A61N 1/327 (2013.01); A61B 2017/00039 (2013.01); A61B 2017/0019 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/00708 (2013.01); A61B 2018/00761 (2013.01); A61B 2018/00875 (2013.01); A61N 2001/083 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for monitoring administration of electrical pulses comprising:
administering a plurality of electrical pulses to a material or a tissue;
obtaining a reference impedance measurement or spectrum relating to the material or tissue;
identifying any change in impedance relative to the reference impedance measurement or spectrum by measuring inter-burst and intra-burst impedance; and
monitoring the administering to determine if a desired endpoint is reached as indicated by the change in impedance, and i) adjusting one or more parameters of, ii) stopping, iii) halting, and/or iv) continuing the administering based on the monitoring.