US 12,214,149 B2
Applicator system containing a microneedle array which comprises an active ingredient for wound healing
Stefan Henke, Kirchen (DE); and Karsten Heuser, Bad Breisig (DE)
Assigned to LTS LOHMANN THERAPIE-SYSTEME AG, Andemach (DE)
Appl. No. 16/634,592
Filed by LTS LOHMANN THERAPIE-SYSTEME AG, Andernach (DE)
PCT Filed Aug. 4, 2018, PCT No. PCT/EP2018/071209
§ 371(c)(1), (2) Date Jan. 28, 2020,
PCT Pub. No. WO2019/025625, PCT Pub. Date Feb. 7, 2019.
Claims priority of application No. 10 2017 117784.1 (DE), filed on Aug. 4, 2017.
Prior Publication US 2020/0188649 A1, Jun. 18, 2020
Int. Cl. A61M 37/00 (2006.01); A61K 9/00 (2006.01); A61K 31/164 (2006.01); A61K 31/17 (2006.01); A61K 31/728 (2006.01); A61K 36/63 (2006.01); A61K 36/886 (2006.01); A61K 38/39 (2006.01)
CPC A61M 37/0015 (2013.01) [A61K 9/0021 (2013.01); A61K 31/164 (2013.01); A61K 31/17 (2013.01); A61K 31/728 (2013.01); A61K 36/63 (2013.01); A61K 36/886 (2013.01); A61K 38/39 (2013.01); A61M 2037/0023 (2013.01)] 12 Claims
 
1. An applicator system comprising a microneedle array for use for the intradermal delivery of a first active ingredient, the applicator system comprising:
a plurality of microneedles on a carrier, wherein the microneedles are made of a polymer matrix in which at least one second active ingredient for wound healing is integrated or incorporated;
a trigger mechanism; and
at least one reservoir for storing the first active ingredient, the reservoir being in connection to the microneedles; and
wherein the first active ingredient is different from the at least one second active ingredient for wound healing, and the first active ingredient is a medicinal drug;
wherein the at least one second active ingredient for wound healing is selected from the group consisting of dexpanthenol, collagen, hyaluronic acid, and combinations thereof; and
wherein the polymer of the polymer matrix is selected from the group consisting of polylactides, polyglycolides, polylactide-co-glycolides, polyanhydrides, poly(ortho)esters, polyurethanes, polybutyric acids, polyvaleric acids, polylactide-co-caprolactones, polycarbonates, polyesters, polyvinyl chloride, polyacrylamides, cycloolefin (co)polymers, polymethacrylates, and thermoplastics.