US 12,214,146 B2
Controlled release of a hydrophilic agent from a coated surface
William James Work, Perkiomenville, PA (US); Raymond Joseph Gould, Thorndale, PA (US); Dhruv Patel, Colmar, PA (US); and Robert W Hergenrother, Huntingdon Valley, PA (US)
Assigned to Biocoat, Incorporated, Horsham, PA (US)
Filed by Biocoat, Incorporated, Horsham, PA (US)
Filed on Dec. 10, 2020, as Appl. No. 17/118,143.
Claims priority of provisional application 62/946,523, filed on Dec. 11, 2019.
Prior Publication US 2021/0178129 A1, Jun. 17, 2021
Int. Cl. A61M 25/10 (2013.01); A61K 31/145 (2006.01); A61K 31/155 (2006.01); A61K 31/165 (2006.01); A61K 31/166 (2006.01); A61K 31/167 (2006.01); A61K 31/437 (2006.01); A61K 31/4409 (2006.01); A61K 31/473 (2006.01); A61K 31/502 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/52 (2006.01); A61K 31/53 (2006.01); A61K 31/5377 (2006.01); A61K 31/655 (2006.01); A61K 31/7008 (2006.01); A61K 31/7048 (2006.01); A61K 31/7076 (2006.01); A61K 31/708 (2006.01); A61L 29/08 (2006.01); A61L 29/16 (2006.01); B05D 5/00 (2006.01); B05D 7/00 (2006.01)
CPC A61M 25/10 (2013.01) [A61K 31/145 (2013.01); A61K 31/155 (2013.01); A61K 31/165 (2013.01); A61K 31/166 (2013.01); A61K 31/167 (2013.01); A61K 31/437 (2013.01); A61K 31/4409 (2013.01); A61K 31/473 (2013.01); A61K 31/502 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/52 (2013.01); A61K 31/53 (2013.01); A61K 31/5377 (2013.01); A61K 31/655 (2013.01); A61K 31/7008 (2013.01); A61K 31/7048 (2013.01); A61K 31/7076 (2013.01); A61K 31/708 (2013.01); A61L 29/085 (2013.01); A61L 29/16 (2013.01); B05D 5/00 (2013.01); B05D 7/542 (2013.01); B05D 7/544 (2013.01); A61L 2300/204 (2013.01); A61L 2300/206 (2013.01); A61L 2300/208 (2013.01); A61L 2300/21 (2013.01); A61L 2300/216 (2013.01); A61L 2300/232 (2013.01); A61L 2300/402 (2013.01); A61L 2300/404 (2013.01); A61L 2300/406 (2013.01); A61L 2300/41 (2013.01); A61L 2300/416 (2013.01); A61L 2300/442 (2013.01); A61L 2420/02 (2013.01); A61L 2420/08 (2013.01); A61M 2025/105 (2013.01); A61M 2207/00 (2013.01)] 30 Claims
OG exemplary drawing
 
1. An implantable medical device comprising:
a base coat layer having an inner and outer surface, the inner surface of the base coat layer contacting the implantable medical device;
a top-coat layer of a hydrophilic polymer chemically crosslinked and covalently bonded to the outer surface of the base coat layer, the hydrophilic polymer comprising an anionic polyelectrolyte, wherein the hydrophilic polymer comprises a poly(acrylic acid) copolymer; and
an amount of a hydrophilic cationic drug agent added to the top-coat layer sufficient to provide an effective dosage of the drug agent for delivery to a patient,
whereby the hydrophilic cationic drug agent is initially adsorbed into the anionic polyelectrolyte of the top-coat layer and the hydrophilic cationic drug agent having a release rate after the medical device is implanted within a patient's body,
wherein the hydrophilic cationic drug agent is selected from a group consisting of a class of water soluble, protonated amine drugs.