	US 12,214,141 B2
	Method to shift circadian rhythm responsive to future therapy
Steven Lockley, Somerville, MA (US); Tony Hanna, Copenhagen (DK); Jacob Ravn, Hammenhoeg (SE); Mickey Beyer-Clausen, Southampton, NY (US); and Fredric Maxik, Cocoa Beach, FL (US)
Assigned to Timeshifter, Inc., Southampton, NY (US)
Filed by Timeshifter, Inc., Southampton, NY (US)
Filed on Feb. 12, 2021, as Appl. No. 17/248,911.
Application 17/248,911 is a continuation in part of application No. 16/949,843, filed on Nov. 17, 2020, abandoned.
Application 17/248,911 is a continuation in part of application No. 16/432,544, filed on Jun. 5, 2019.
Claims priority of provisional application 62/680,887, filed on Jun. 5, 2018.
Prior Publication US 2021/0162164 A1, Jun. 3, 2021
Int. Cl. A61M 21/02 (2006.01); A61M 21/00 (2006.01); G16H 20/60 (2018.01); G16H 20/70 (2018.01)

CPC A61M 21/02 (2013.01) [G16H 20/60 (2018.01); G16H 20/70 (2018.01); A61M 2021/0044 (2013.01); A61M 2205/587 (2013.01)]

19 Claims

1. A method of determining and facilitating shifting of a circadian rhythm of a user to improve the effectiveness of a future therapy by a server comprising a processor, the method comprising:

receiving at the server a future therapy indication comprising:

a therapy to be administered;

a therapy date defining the day the therapy will be administered; and

a therapy time defining a time of day the therapy will be administered;

identifying by the processor one or more periods during a circadian cycle during which performance of the therapy is preferred, defining a circadian performance time range;

receiving at the server an indication of a normal circadian rhythm of the user;

determining by the processor the position of the circadian performance time range within the normal circadian rhythm of the user, defining a user circadian performance time range;

identifying by the processor a circadian shift necessary to change the user circadian performance time range such that the therapy time occurs within the user circadian performance time range, the circadian shift comprising a circadian shift direction and a circadian shift magnitude;

receiving at the server an indication of a present circadian phase of the user;

defining by the processor a user circadian shift protocol responsive to the circadian shift direction, circadian shift magnitude, and a number of days between a present day and the therapy date, the user circadian shift protocol comprising one or more activities scheduled to be performed at a certain date and time and comprising:

receiving at the server an indication of a second activity to be performed and comprised by the one or more activities;

determining by the processor a first time of day to perform a first activity of the one or more activities corresponding to the user circadian performance time range responsive to the present circadian phase of the user and the second activity, defining a first activity clock performance time;

identifying by the processor one or more periods during a circadian cycle during which performance of the second activity is preferred responsive to the first activity, defining a second activity circadian performance time;

determining by the processor the position of the second circadian performance time within the normal circadian rhythm of the user, defining a second activity user circadian performance time; and

determining by the processor a second time of day corresponding to the second activity user circadian performance time, defining a second activity clock performance time;

providing by the processor a first indication to perform the first activity of the one or more activities comprised by the user circadian shift protocol at the first activity clock performance time comprising at least one of illuminating a first indicator light, operating a sound-generating device to provide a first audio indication, operating a visual display to display a first message, and transmitting a first message to be received on a computerized device; and;

providing by the processor a second indication to the user to perform the second activity at the second activity clock performance comprising at least one of illuminating a second indicator light that is differentiated from the first indicator light, operating a sound-generating device to provide a second audio indication that is differentiated from the first audio indication, operating a visual display to display a second message that is differentiated from the first message, and transmitting a second message that is differentiated from the first message to be received on the computerized device.