US 12,214,118 B2
Electrical condensation aerosol device
David Koji Hasegawa, Cupertino, CA (US); Mingzu Lei, San Jose, CA (US); and Gilbert T. Tong, Union City, CA (US)
Assigned to ALEXZA PHARMACEUTICALS, INC., Mountain View, CA (US)
Appl. No. 16/966,785
Filed by ALEXZA PHARMACEUTICALS, INC., Mountain View, CA (US)
PCT Filed Feb. 1, 2019, PCT No. PCT/US2019/016398
§ 371(c)(1), (2) Date Jul. 31, 2020,
PCT Pub. No. WO2019/152873, PCT Pub. Date Aug. 8, 2019.
Claims priority of provisional application 62/626,396, filed on Feb. 5, 2018.
Claims priority of provisional application 62/626,388, filed on Feb. 5, 2018.
Claims priority of provisional application 62/625,757, filed on Feb. 2, 2018.
Prior Publication US 2021/0046259 A1, Feb. 18, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61M 11/04 (2006.01); A24F 40/20 (2020.01); A24F 40/50 (2020.01); A61M 11/00 (2006.01)
CPC A61M 11/042 (2014.02) [A61M 11/001 (2014.02); A24F 40/20 (2020.01); A24F 40/50 (2020.01); A61M 2205/0233 (2013.01); A61M 2205/3334 (2013.01); A61M 2205/3368 (2013.01); A61M 2205/6054 (2013.01); A61M 2205/6072 (2013.01); A61M 2205/8206 (2013.01)] 26 Claims
OG exemplary drawing
 
1. A drug device for producing condensation aerosol by thermal vaporization of a drug comprising:
a disposable cartridge (200); and
a handheld medical device (100), comprising:
a) one or more air inlets (107);
b) one or more air outlets (103);
c) one or more batteries (105) to provide electric current;
d) one or more connectors to electrically connect the device (100) to the_disposable cartridge (200) comprising a drug composition (210) coated on a foil substrate (209); and
e) one or more electrical current delivery devices (106) to control the release of electric current to the disposable cartridge (200);
said air inlets (107) and air outlets (103) defining an airway;
at least one of the one or more air outlets (103)] being configured as a housing to attach said disposable cartridge (200);
said electrical current delivery devices (106) being configured to drive a precise electrical current profile to the foil substrate (209) of the disposable cartridge (200) to affect electrical resistive heating at a rate that achieves a precise temperature profile with a controllable ramp-up to a target temperature and heating rate; and
the temperature profile is suitable to vaporize a therapeutically effective amount of the drug composition (210) coated on the foil substrate (209) of the cartridge (200) within a period of 3 seconds or less followed by condensation inside the cartridge of the resulting vapor to form drug aerosol particles
wherein the one or more connectors and the foil substrate (209) are electrically connected through a printed circuit board (211) or a flex circuit (207).