US 12,214,106 B2
Compositions comprising silk fibroin particles and uses thereof
Anh Hoang-Lindsay, Boston, MA (US); Christopher P. Gulka, Melrose, MA (US); Jodie E. M. Giordano, Bedford, MA (US); Joseph E. Brown, Melrose, MA (US); and Thomas L. Carroll, Melrose, MA (US)
Assigned to Sofregen Medical, Inc., Framingham, MA (US)
Filed by Sofregen Medical, Inc., Framingham, MA (US)
Filed on Mar. 7, 2023, as Appl. No. 18/179,777.
Application 18/179,777 is a continuation of application No. 17/200,766, filed on Mar. 12, 2021, granted, now 11,623,019.
Application 17/200,766 is a continuation of application No. 15/799,455, filed on Oct. 31, 2017, granted, now 11,617,815.
Claims priority of provisional application 62/571,670, filed on Oct. 12, 2017.
Claims priority of provisional application 62/488,402, filed on Apr. 21, 2017.
Claims priority of provisional application 62/482,949, filed on Apr. 7, 2017.
Claims priority of provisional application 62/415,107, filed on Oct. 31, 2016.
Prior Publication US 2023/0355836 A1, Nov. 9, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/22 (2006.01); A61L 27/26 (2006.01); A61L 27/50 (2006.01); A61L 27/56 (2006.01); C08K 5/00 (2006.01); C08K 5/053 (2006.01); C08L 5/08 (2006.01); C08L 89/00 (2006.01)
CPC A61L 27/227 (2013.01) [A61L 27/26 (2013.01); A61L 27/502 (2013.01); A61L 27/56 (2013.01); C08K 5/0016 (2013.01); C08K 5/053 (2013.01); C08L 5/08 (2013.01); C08L 89/00 (2013.01); A61L 2400/06 (2013.01); A61L 2430/34 (2013.01)] 8 Claims
 
1. An injectable composition comprising:
crosslinked hyaluronic acid; and
silk fibroin particles having an average particle size of about 50 um to about 1000 um, wherein:
the crosslinked hyaluronic acid has a crosslink density of about 4 mol % to about 30 mol %,
the crosslinked hyaluronic acid has a concentration in the injectable composition of greater than or equal to about 1% (w/v) and less than or equal to about 10% (w/v),
the silk fibroin particles are hydrated, and
the silk fibroin particles have an average hydrated density of about 0.4 g/mL particles to about 1 g/mL particles.