US 12,214,093 B2
Pathogen reduced platelet compositions and related methods
Steven Charlebois, West Lafayette, IN (US); and Sreedhar Thirumala, Zionsville, IN (US)
Assigned to SEXTON BIOTECHNOLOGIES, INC., Indianapolis, IN (US)
Filed by SEXTON BIOTECHNOLOGIES, INC., Indianapolis, IN (US)
Filed on Dec. 20, 2018, as Appl. No. 16/227,094.
Claims priority of provisional application 62/608,498, filed on Dec. 20, 2017.
Prior Publication US 2019/0269808 A1, Sep. 5, 2019
Int. Cl. A61L 2/00 (2006.01); A61K 35/19 (2015.01); A61K 35/28 (2015.01); A61P 37/00 (2006.01); C12N 5/0775 (2010.01); C12N 5/078 (2010.01)
CPC A61L 2/007 (2013.01) [A61K 35/19 (2013.01); A61K 35/28 (2013.01); A61P 37/00 (2018.01); C12N 5/0644 (2013.01); C12N 5/0662 (2013.01); A61L 2202/22 (2013.01); C12N 2500/84 (2013.01); C12N 2501/11 (2013.01); C12N 2501/115 (2013.01); C12N 2501/135 (2013.01); C12N 2501/15 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A method for making a pathogen reduced platelet composition, comprising:
irradiating a frozen composition comprising a platelet lysate with electron beam radiation having an energy level of 5 MeV to 15 MeV,
wherein the irradiating is conducted to apply 60 kGy to 100 kGy of electron beam radiation to the frozen composition,
wherein the electron beam radiation is applied to a first side of the frozen composition and to a second side of the frozen composition opposite the first side, and wherein a thickness of the frozen composition between the first side and the second side is 0.5-5 cm.