US 12,214,087 B2
Thermostable quick-dissolving thin film
Christophe Debacq, Rixensart (BE); Phillip Lovalenti, San Jose, CA (US); Van Nguyen, San Jose, CA (US); Laurence Plapied, Rixensart (BE); Laurent Strodiot, Rixensart (BE); and Austin Wuerfel, San Jose, CA (US)
Appl. No. 17/438,116
Filed by GLAXOSMITHKLINE BIOLOGICALS SA, Rixensart (BE); and ARIDIS PHARMACEUTICALS, INC., San Jose, CA (US)
PCT Filed Mar. 17, 2020, PCT No. PCT/EP2020/057268
§ 371(c)(1), (2) Date Sep. 10, 2021,
PCT Pub. No. WO2020/187903, PCT Pub. Date Sep. 24, 2020.
Claims priority of provisional application 62/820,432, filed on Mar. 19, 2019.
Prior Publication US 2022/0183993 A1, Jun. 16, 2022
Int. Cl. A61K 9/70 (2006.01); A61K 9/00 (2006.01); A61K 47/12 (2006.01); A61K 47/18 (2017.01); A61K 47/22 (2006.01); A61K 47/26 (2006.01); A61K 47/32 (2006.01)
CPC A61K 9/7007 (2013.01) [A61K 9/006 (2013.01); A61K 47/12 (2013.01); A61K 47/183 (2013.01); A61K 47/22 (2013.01); A61K 47/26 (2013.01); A61K 47/32 (2013.01)] 20 Claims
 
1. A quick-dissolving thin film comprising a virus and an excipient mix, wherein said excipient mix comprises
one or more water-soluble polymer(s),
trehalose,
a metal ion,
a carboxylate, and
a buffering agent,
wherein said quick-dissolving thin film is thermostable, and
wherein said quick-dissolving thin film does not comprise any animal derived product or gelatin.