US 12,214,071 B2
Topical composition containing antioxidants
Aldo Laghi, Pinellas Park, FL (US); and Nathaniel Vint, Palm Harbor, FL (US)
Filed by Alps South Europe, Plzen (CZ)
Filed on Sep. 22, 2023, as Appl. No. 18/371,619.
Application 17/865,436 is a division of application No. 16/691,642, filed on Nov. 22, 2019, granted, now 11,478,419, issued on Oct. 25, 2022.
Application 17/865,436 is a division of application No. 14/711,383, filed on May 13, 2015, granted, now 10,543,167, issued on Jan. 28, 2020.
Application 18/371,619 is a continuation of application No. 17/865,436, filed on Jul. 15, 2022, granted, now 11,806,427.
Claims priority of provisional application 62/051,534, filed on Sep. 17, 2014.
Prior Publication US 2024/0065968 A1, Feb. 29, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/235 (2006.01); A61K 8/06 (2006.01); A61K 8/67 (2006.01); A61K 9/00 (2006.01); A61K 9/107 (2006.01); A61K 31/355 (2006.01); A61K 47/10 (2017.01); A61K 47/14 (2017.01); A61K 47/18 (2017.01); A61K 47/44 (2017.01); A61Q 19/08 (2006.01)
CPC A61K 9/0014 (2013.01) [A61K 8/062 (2013.01); A61K 8/678 (2013.01); A61K 9/107 (2013.01); A61K 31/235 (2013.01); A61K 31/355 (2013.01); A61K 47/10 (2013.01); A61K 47/14 (2013.01); A61K 47/18 (2013.01); A61K 47/44 (2013.01); A61K 2800/522 (2013.01); A61K 2800/524 (2013.01); A61Q 19/08 (2013.01)] 3 Claims
OG exemplary drawing
 
1. A topical composition comprising:
30-75 percent by weight water;
3-6 percent by weight surfactant;
1-50 percent by weight lipophilic carrier having a molecular weight between 150 and 600;
0.25-4 percent by weight lipophilic antioxidant having a formula:

OG Complex Work Unit Chemistry
wherein:
R1 represents a C1 to C9 linear or branched alkyl group or styrene;
R2 is optional and represents a C1 to C6 linear or branched alkyl group or styrene;
Y1 represents a C1 to C6 linear or branched alkyl group, styrene, —SR5, or —(CH2)nCOOR6;
n is from 1 to 10;
R5 represents isoprene, a methyl group, an ethyl group, a propyl, a butyl, a pentyl group, a hexyl group, an isopropyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, a tert-pentyl group, a neo-pentyl group, an isopentyl group, an isohexyl group, a neohexyl group, styrene, or

OG Complex Work Unit Chemistry
wherein R11, R12, and R13 independently represent OH, a methyl group, ethyl group, a propyl group, a butyl group, an isopropyl group, a tert-butyl group, an isoprene, or a tert-pentyl group;
R6 represents an alkyl group having C10 to C30;
and
wherein the formula includes pharmaceutically acceptable salts thereof;
1-10 percent by weight skin penetration enhancer;
9-11 percent by weight paraffinic oil; and
0.5-5 percent by weight of a preservative mixture comprising propylene glycol, diazolidinyl urea, methylparaben, and propylparaben and tetrasodium ethylenediaminetetraacetic acid;
wherein once the topical composition is compounded, the topical composition is a cream emulsion.