	US 12,214,044 B2
	Factor VIII zwitterionic polymer conjugates
Stephen A. Charles, Ravenna, OH (US); Daniel Victor Perlroth, Palo Alto, CA (US); Li Song, Cupertino, CA (US); Martin Linsell, San Mateo, CA (US); Wayne To, San Mateo, CA (US); Didier Benoit, San Jose, CA (US); and James Aggen, Westwood, MA (US)
Assigned to KODIAK SCIENCES INC., Palo Alto, CA (US)
Filed by KODIAK SCIENCES INC., Palo Alto, CA (US)
Filed on Feb. 7, 2023, as Appl. No. 18/165,774.
Application 18/165,774 is a continuation of application No. 16/781,869, filed on Feb. 4, 2020, granted, now 11,590,235.
Application 16/781,869 is a continuation of application No. 14/916,180, granted, now 10,702,608, issued on Jul. 7, 2020, previously published as PCT/US2014/054622, filed on Sep. 8, 2014.
Claims priority of provisional application 61/875,099, filed on Sep. 8, 2013.
Prior Publication US 2023/0173081 A1, Jun. 8, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/00 (2006.01); A61K 38/37 (2006.01); A61K 47/59 (2017.01); A61K 47/60 (2017.01); A61K 47/64 (2017.01); C07K 14/755 (2006.01); C08F 120/36 (2006.01); C08G 65/333 (2006.01)

CPC A61K 47/60 (2017.08) [A61K 38/37 (2013.01); A61K 47/59 (2017.08); A61K 47/64 (2017.08); C07K 14/755 (2013.01); C08F 120/36 (2013.01); C08G 65/33324 (2013.01)]

15 Claims

1. A compound having the following formula:

wherein s is 1-20;

p is 1 to 12;

R2 is selected from the group consisting of alkyl, substituted alkyl, alkylene, alkoxy, carboxyalkyl, haloalkyl, cycloalkyl, cyclic alkyl ether, alkenyl, alkenylene, alkynyl, alkynylene, cycloalkylene, heterocycloalkyl, heterocycloalkylene, aryl, arylene, arylene-oxy, heteroaryl, amino, amido or any combination thereof; and

R3 is

wherein R4, R5, and R6 are the same or different and are selected from the group consisting of:

and

wherein Z is polymer, the polymer is synthesized with a monomer selected from the group consisting of:

wherein

R7 is H or C₁-6 alkyl, ZW is a zwitterion, and t is 1 to 6.