	US 12,214,043 B2
	Therapeutic nanomaterials
Yupeng Chen, Farmington, CT (US); Jinhyung Lee, Farmington, CT (US); and Wuxia Zhang, Farmington, CT (US)
Filed by University of Connecticut, Farmington, CT (US)
Filed on Oct. 29, 2021, as Appl. No. 17/514,390.
Claims priority of provisional application 63/106,934, filed on Oct. 29, 2020.
Prior Publication US 2022/0133893 A1, May 5, 2022
Int. Cl. A61K 47/54 (2017.01); A61K 31/194 (2006.01); A61K 31/51 (2006.01); A61K 31/519 (2006.01); A61K 31/721 (2006.01); A61K 31/722 (2006.01); A61K 31/727 (2006.01); A61K 31/728 (2006.01); A61K 38/19 (2006.01); A61K 38/36 (2006.01); A61K 38/38 (2006.01); A61K 38/40 (2006.01); A61K 47/65 (2017.01); A61K 47/69 (2017.01); A61P 31/12 (2006.01)

CPC A61K 47/545 (2017.08) [A61K 31/194 (2013.01); A61K 31/51 (2013.01); A61K 31/519 (2013.01); A61K 31/721 (2013.01); A61K 31/722 (2013.01); A61K 31/727 (2013.01); A61K 31/728 (2013.01); A61K 38/19 (2013.01); A61K 38/363 (2013.01); A61K 38/385 (2013.01); A61K 38/40 (2013.01); A61K 47/65 (2017.08); A61K 47/6929 (2017.08); A61P 31/12 (2018.01)]

2 Claims

1. A composition comprising a compound of Formula (I):

or a pharmaceutically acceptable salt thereof, wherein:

R¹is H or CH₃;

R²is (CH₂)_j, (CH₂CH₂O)_kor (CH₂CH₂NH)_m;

j, k, and m are the chemical subscripts for the moieties listed in R2 and each it independently represents 0-200 of the repeating moieties;

L is absent; and

X is folic acid

wherein the composition has a pH of about 1 to about 10.