US 12,214,039 B2
Systems and methods for treatments of an eye with a photosensitizer
Pavel Kamaev, Lexington, MA (US); and Marc D. Friedman, Needham, MA (US)
Assigned to Advero, Inc., Waltham, MA (US)
Filed by Avedro, Inc., Waltham, MA (US)
Filed on Oct. 25, 2021, as Appl. No. 17/509,238.
Application 17/509,238 is a continuation of application No. 15/216,344, filed on Jul. 21, 2016, granted, now 11,207,410.
Claims priority of provisional application 62/263,598, filed on Dec. 4, 2015.
Claims priority of provisional application 62/262,919, filed on Dec. 4, 2015.
Claims priority of provisional application 62/255,452, filed on Nov. 14, 2015.
Claims priority of provisional application 62/195,144, filed on Jul. 21, 2015.
Prior Publication US 2022/0152202 A1, May 19, 2022
Int. Cl. A61K 41/00 (2020.01); A61F 9/00 (2006.01); A61F 9/007 (2006.01); A61K 9/00 (2006.01); A61K 31/525 (2006.01); A61K 33/00 (2006.01); A61K 33/26 (2006.01); A61N 5/06 (2006.01); A61P 27/02 (2006.01); A61P 43/00 (2006.01)
CPC A61K 41/0057 (2013.01) [A61F 9/0017 (2013.01); A61F 9/0079 (2013.01); A61K 9/0048 (2013.01); A61K 31/525 (2013.01); A61K 33/00 (2013.01); A61K 33/26 (2013.01); A61N 5/062 (2013.01); A61P 27/02 (2018.01); A61P 43/00 (2018.01); A61N 2005/0661 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method for treating corneal damage associated with a pathogen infection in an eye, comprising:
identifying an eye infected by a pathogen;
applying an eye drop formulation to an area of the eye infected by the pathogen, the formulation including:
a photosensitizer;
one or more non-ionic permeability enhancers; and
at least one additive selected from the group consisting of iron, copper, manganese, chromium, vanadium, aluminum, cobalt, mercury, cadmium, nickel, arsenic, 2,3-butanedione, and folic acid; and
delivering a dose of illumination having a fluence rate ranging from about 15 mW/cm2 to about 45 mW/cm2 in combination with pulsed oxygen to the area of the eye thereby photoactivating the photosensitizer and cross-linking corneal tissue at a depth that does not damage endothelium.