	US 12,214,033 B2
	Virus purification
Jana Barbero Calzado, Vienna (AT); Mario Nebenführ, Vienna (AT); Robert Schlegl, Siegenfield (AT); Michael Weber, Vienna (AT); and Jürgen Heindl-Wruss, Vienna (AT)
Assigned to Valneva SE, Nantes (FR)
Filed by Valneva SE, Nantes (FR)
Filed on Jul. 6, 2022, as Appl. No. 17/811,059.
Application 17/811,059 is a continuation of application No. 16/840,760, filed on Apr. 6, 2020, granted, now 11,406,700.
Application 16/840,760 is a continuation of application No. 15/781,959, granted, now 10,660,950, issued on May 26, 2020, previously published as PCT/EP2016/082663, filed on Dec. 23, 2016.
Claims priority of application No. 15202585 (EP), filed on Dec. 23, 2015; application No. 16161068 (EP), filed on Mar. 18, 2016; application No. 16176025 (EP), filed on Jun. 23, 2016; application No. 16176049 (EP), filed on Jun. 23, 2016; and application No. 16182845 (EP), filed on Aug. 4, 2016.
Prior Publication US 2023/0056142 A1, Feb. 23, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/12 (2006.01); A61K 39/39 (2006.01); A61P 31/14 (2006.01); C07K 14/18 (2006.01); C12N 7/00 (2006.01); C12N 7/02 (2006.01); C12N 7/06 (2006.01); A61K 39/00 (2006.01)

CPC A61K 39/12 (2013.01) [A61K 39/39 (2013.01); A61P 31/14 (2018.01); C07K 14/18 (2013.01); C07K 14/1825 (2013.01); C12N 7/00 (2013.01); C12N 7/02 (2013.01); C12N 7/06 (2013.01); A61K 2039/5252 (2013.01); A61K 2039/5254 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/55505 (2013.01); C12N 2770/24134 (2013.01); C12N 2770/24151 (2013.01); C12N 2770/24163 (2013.01); Y02A 50/30 (2018.01)]

14 Claims

1. A method for separating infectious virus particles from non-infectious virus particles comprising precipitating the non-infectious virus particles with protamine, wherein the virus particles are selected from the group consisting of Paramyxoviridae, Orthomyxoviridae, Flaviviridae, Filoviridae, Arenaviridae, Rhabdoviridae, Togaviridae and Coronaviridae, and wherein the virus particles are not Zika virus particles.