	US 12,214,030 B2
	*Self-adjuvanting Yersinia* outer membrane vesicle as a vaccine against plague, anthrax and pseudomonas infection**
Wei Sun, Glenmont, NY (US)
Assigned to Albany Medical College, Albany, NY (US)
Filed by Albany Medical College, Albany, NY (US)
Filed on Sep. 23, 2021, as Appl. No. 17/482,527.
Application 17/482,527 is a continuation of application No. 17/117,417, filed on Dec. 10, 2020, granted, now 11,167,019.
Claims priority of provisional application 62/947,585, filed on Dec. 13, 2019.
Prior Publication US 2022/0280628 A1, Sep. 8, 2022
Int. Cl. A61K 39/02 (2006.01); A61K 39/104 (2006.01); A61P 31/04 (2006.01); A61K 39/00 (2006.01)

CPC A61K 39/0291 (2013.01) [A61K 39/104 (2013.01); A61P 31/04 (2018.01); A61K 2039/55594 (2013.01)]

14 Claims

1. A vaccine platform, comprising a plurality of non-naturally occurring outer membrane vesicles produced from a Yersinia bacterium, wherein the outer membrane vesicles enclose monophosphoryl lipid A and an amount of a heterologous PcrV-HitAT fusion antigen of Pseudomonas aeruginosa.