US 12,214,020 B2
PTH prodrugs
Kennett Sprogøe, Holte (DK); Felix Cleemann, Mainz (DE); Guillaume Maitro, Mannheim (DE); Mathias Krusch, Hirschhorn (DE); Thomas Wegge, Heidelberg (DE); and Joachim Zettler, Heidelberg (DE)
Assigned to ASCENDIS PHARMA BONE DISEASES A/S, Hellerup (DK)
Filed by ASCENDIS PHARMA BONE DISEASES A/S, Hellerup (DK)
Filed on Sep. 8, 2023, as Appl. No. 18/464,046.
Application 18/464,046 is a continuation of application No. 18/053,693, filed on Nov. 8, 2022, granted, now 11,793,861.
Application 18/053,693 is a continuation of application No. 17/488,137, filed on Sep. 28, 2021, abandoned.
Application 17/488,137 is a continuation of application No. 16/118,155, abandoned, previously published as PCT/EP2017/054550, filed on Feb. 28, 2017.
Claims priority of application No. 16158048 (EP), filed on Mar. 1, 2016; application No. 16179294 (EP), filed on Jul. 13, 2016; application No. 16191484 (EP), filed on Sep. 29, 2016; and application No. 17155839 (EP), filed on Feb. 13, 2017.
Prior Publication US 2024/0123038 A1, Apr. 18, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/29 (2006.01); A61K 9/00 (2006.01); A61K 47/54 (2017.01); A61K 47/60 (2017.01)
CPC A61K 38/29 (2013.01) [A61K 9/0019 (2013.01); A61K 47/54 (2017.08); A61K 47/545 (2017.08); A61K 47/60 (2017.08)] 9 Claims
 
1. A method of treating a patient having hypoparathyroidism comprising administering to the patient a therapeutically effective amount of a compound according to formula 31

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, thereby treating hypoparathyroidism in the patient,
wherein PTH(1-34) is parathyroid hormone of the amino acid sequence SEQ ID NO:51, NαS1 is the alpha amino group of the N-terminal serine of SEQ ID NO:51 and 2×10 kDa PEG comprises a branched polyethylene glycol polymer of two arms in which each arm has a molecular weight of about 10 kDa and is a moiety of formula (b)

OG Complex Work Unit Chemistry
wherein the dashed line indicates attachment to —S— in compound 31, and each of m and p of each moiety is independently an integer.