US 12,214,019 B2
Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
Mercedes Morales, San Francisco, CA (US); Mir Imran, Los Altos Hills, CA (US); Radhika Korupolu, Fremont, CA (US); and Mir Hashim, Fremont, CA (US)
Assigned to Rani Therapeutics, LLC, San Jose, CA (US)
Filed by Rani Therapeutics, LLC, San Jose, CA (US)
Filed on Mar. 14, 2022, as Appl. No. 17/694,507.
Application 17/694,507 is a continuation of application No. 16/112,558, filed on Aug. 24, 2018, granted, now 11,304,993.
Application 16/112,558 is a continuation of application No. 14/714,120, filed on May 15, 2015, granted, now 10,098,931.
Claims priority of provisional application 62/159,134, filed on May 8, 2015.
Claims priority of provisional application 62/156,105, filed on May 1, 2015.
Claims priority of provisional application 61/993,907, filed on May 15, 2014.
Prior Publication US 2022/0202910 A1, Jun. 30, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/28 (2006.01); A61K 9/20 (2006.01); A61K 38/26 (2006.01); C07K 16/00 (2006.01); C07K 16/24 (2006.01)
CPC A61K 38/28 (2013.01) [A61K 9/2018 (2013.01); A61K 9/2027 (2013.01); A61K 9/2031 (2013.01); A61K 9/2072 (2013.01); A61K 9/2077 (2013.01); A61K 38/26 (2013.01); C07K 16/00 (2013.01); C07K 16/241 (2013.01); C07K 16/244 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/76 (2013.01)] 19 Claims
 
1. A shaped mass comprising a biologically active protein or polypeptide and a pharmaceutical excipient, the shaped mass formed by compression of a precursor material comprising the biologically active protein or polypeptide, wherein an amount of biologically active protein or polypeptide in the shaped mass is at least 70% of that in the precursor material, the shaped mass having a density in a range of about 0.80 mg/mm3 to about 1.15 mg/mm3.