	US 12,213,994 B2
	Compositions and methods for treating pain with extracellular vesicles
Maria Ines Mitrani, Miami Beach, FL (US); Michael Bellio, Miami, FL (US); and Albert Mitrani, Miami, FL (US)
Assigned to Zeo ScientifiX, Inc., Fort Lauderdale, FL (US)
Filed by Organicell Regenerative Medicine, Inc., Miami, FL (US)
Filed on Dec. 8, 2022, as Appl. No. 18/063,227.
Claims priority of provisional application 63/287,466, filed on Dec. 8, 2021.
Prior Publication US 2023/0277588 A1, Sep. 7, 2023
Int. Cl. A61K 35/14 (2015.01); A61K 9/00 (2006.01); A61K 9/127 (2006.01); A61K 47/64 (2017.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01)

CPC A61K 35/14 (2013.01) [A61K 9/0014 (2013.01); A61K 9/127 (2013.01); A61K 47/6425 (2017.08); A61P 19/02 (2018.01); A61P 29/00 (2018.01)]

30 Claims

1. A method of treating a disease or disorder in a subject in need thereof, the method comprising:

administering to the subject having the disease or disorder a therapeutically effective amount of a composition comprising:

blood-derived nanoparticles, the blood-derived nanoparticles having a diameter less than 200 nm, the blood-derived nanoparticles derived from substantially platelet-free and cell-free blood, and

a concentration of blood-derived nanoparticles in the composition being at least 1×10⁸nanoparticles/ml.