US 12,213,993 B2
Coated medicinal clay compositions, pharmaceutical compositions, and delivery of cation sources and methods of use thereof
Darlene E. McCord, Chattanooga, TN (US); and Alex Hovey, North Liberty, IA (US)
Assigned to Darlene E. McCord, Chattanooga, TN (US)
Filed by Darlene E. McCord, Chattanooga, TN (US)
Filed on Oct. 24, 2022, as Appl. No. 18/049,095.
Claims priority of provisional application 63/364,657, filed on May 13, 2022.
Claims priority of provisional application 63/262,999, filed on Oct. 25, 2021.
Prior Publication US 2023/0131873 A1, Apr. 27, 2023
Int. Cl. A61K 33/26 (2006.01); A61K 33/06 (2006.01); A61K 33/38 (2006.01); A61P 31/04 (2006.01)
CPC A61K 33/26 (2013.01) [A61K 33/06 (2013.01); A61K 33/38 (2013.01); A61P 31/04 (2018.01)] 21 Claims
OG exemplary drawing
 
1. A method of treatment of a subject with a composition comprising: administering to a tissue, organ, or wound optionally wherein the tissue, organ, or wound comprises exudate comprising exudate therefrom of a subject in need of treatment a medicinal clay composition and at least one coating agent surrounding the medicinal clay composition, wherein the medicinal clay composition comprises a cation source and has
a Cation Exchange Capacity of at least about greater than about 10 mEq/100 g,
an Oxidation-Reduction Potential greater than about 250 mV,
a pH less than about 5.0, a crystalline composition comprising smectite, illite,
and/or illite-smectite that is at least about 40 wt-% of the medicinal clay composition,
and less than 40 ppm heavy metal contaminants,
and wherein the at least one coating agent comprises a nonionic block Ethylene oxide-propylene oxide (EO-PO) copolymer with an average molecular weight of from about 5,000 to about 20,000,
wherein said coating agent prevents the premature activation of the medicinal clay composition by surrounding the medicinal clay composition,
wherein the medicinal clay is activated upon contacting a water source,
wherein the medicinal clay composition reduces the pH of the tissue or organ to less than about 4 to promote healing, and reducing microbial populations on the subject and/or removing exudate from the tissue, organ, or wound in need of treatment.