US 12,213,987 B2
Prodrug salts
Marc F. Pelletier, Shaker Heights, OH (US); Paul Robert McGuirk, Spring Hill, FL (US); George William Farr, Rocky River, OH (US); Robert Zamboni, Beaconsfield (CA); John Colucci, Kirkland (CA); and Helmi Zaghdane, Pincourt (CA)
Assigned to Aeromics, Inc., New Haven, CT (US)
Filed by Aeromics, Inc., New Haven, CT (US)
Filed on Jun. 16, 2021, as Appl. No. 17/304,201.
Application 15/792,707 is a division of application No. 15/034,274, granted, now 9,827,253, issued on Nov. 28, 2017, previously published as PCT/US2014/064447, filed on Nov. 6, 2014.
Application 17/304,201 is a continuation of application No. 16/665,333, filed on Oct. 28, 2019, granted, now 11,071,744.
Application 16/665,333 is a continuation of application No. 16/296,663, filed on Mar. 8, 2019, abandoned.
Application 16/296,663 is a continuation of application No. 15/792,707, filed on Oct. 24, 2017, granted, now 10,258,636, issued on Apr. 16, 2019.
Claims priority of provisional application 61/900,946, filed on Nov. 6, 2013.
Claims priority of provisional application 61/900,878, filed on Nov. 6, 2013.
Claims priority of provisional application 61/900,919, filed on Nov. 6, 2013.
Prior Publication US 2022/0143048 A1, May 12, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/661 (2006.01); A61K 9/00 (2006.01); A61K 31/167 (2006.01); A61K 31/222 (2006.01); A61K 31/5375 (2006.01); A61K 47/18 (2017.01); C07F 9/09 (2006.01)
CPC A61K 31/661 (2013.01) [A61K 9/0019 (2013.01); A61K 31/167 (2013.01); A61K 31/222 (2013.01); A61K 31/5375 (2013.01); A61K 47/18 (2013.01); C07F 9/09 (2013.01)] 10 Claims
 
1. A process for synthesizing:

OG Complex Work Unit Chemistry
wherein the process comprises deprotecting:

OG Complex Work Unit Chemistry
with a deprotecting agent and wherein the process further comprises isolating:

OG Complex Work Unit Chemistry