US 12,213,981 B2
Alpha polyglutamated pralatrexate and uses thereof
Clet Niyikiza, Gulph Mills, PA (US); and Victor Mandla Moyo, Ringoes, NJ (US)
Assigned to L.E.A.F. HOLDINGS GROUP LLC, Gulph Mills, PA (US)
Filed by L.E.A.F. HOLDINGS GROUP LLC, Gulph Mills, PA (US)
Filed on May 25, 2023, as Appl. No. 18/201,864.
Application 18/201,864 is a continuation of application No. 16/967,303, granted, now 11,730,738, previously published as PCT/US2019/016971, filed on Feb. 7, 2019.
Claims priority of provisional application 62/764,943, filed on Aug. 17, 2018.
Claims priority of provisional application 62/702,732, filed on Jul. 24, 2018.
Claims priority of provisional application 62/662,374, filed on Apr. 25, 2018.
Claims priority of provisional application 62/630,637, filed on Feb. 14, 2018.
Claims priority of provisional application 62/627,731, filed on Feb. 7, 2018.
Claims priority of provisional application 62/627,741, filed on Feb. 7, 2018.
Prior Publication US 2024/0024326 A1, Jan. 25, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/519 (2006.01); A61K 47/26 (2006.01); A61K 47/54 (2017.01); A61K 47/64 (2017.01); A61K 47/68 (2017.01); A61K 47/69 (2017.01); A61K 49/00 (2006.01); A61P 35/00 (2006.01)
CPC A61K 31/519 (2013.01) [A61K 9/1271 (2013.01); A61K 47/26 (2013.01); A61K 47/542 (2017.08); A61K 47/64 (2017.08); A61K 47/6849 (2017.08); A61K 47/6913 (2017.08); A61K 49/0084 (2013.01); A61P 35/00 (2018.01)] 45 Claims
 
1. A liposomal composition comprising an alpha polyglutamated pralatrexate encapsulated by a liposome, wherein at least one glutamyl group of the polyglutamated pralatrexate has an alpha carboxyl group linkage.