US 12,213,973 B2
Bacterial nitric oxide synthase inhibitors
Richard Bruce Silverman, Evanston, IL (US); and Pathum Manjula Weerawarna, Evanston, IL (US)
Assigned to Northwestern University, Evanston, IL (US)
Filed by Northwestern University, Evanston, IL (US)
Filed on Oct. 18, 2022, as Appl. No. 18/047,497.
Claims priority of provisional application 63/262,692, filed on Oct. 18, 2021.
Prior Publication US 2023/0210840 A1, Jul. 6, 2023
Int. Cl. A61K 31/4709 (2006.01); A61K 45/06 (2006.01); A61P 31/04 (2006.01); C07D 401/12 (2006.01)
CPC A61K 31/4709 (2013.01) [A61K 45/06 (2013.01); A61P 31/04 (2018.01); C07D 401/12 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A compound of a Formula I(a) or I(b), or a salt thereof:

OG Complex Work Unit Chemistry
wherein if the compound has the formula I(a), then:
(i) X is CH2 or O;
L is aza-substituted alkylene of a formula —(CH2)mNH(CH2)n—, m and n being an integer independently selected from 0 to 4; and
R is an optionally substituted pyridyl or an amino; or
(ii) X is CH2 or O;
L is alkylene; and
R is an optionally substituted pyridyl; and
wherein if the compound has the formula I(b), then:
X is O;
L is aza-substituted alkylene; and
R is pyridyl substituted with amino.