US 12,213,960 B2
Method of preventing or improving UV-induced skin damage using hydroangenol as active ingredient
Sun Hee Lee, Seongnam-si (KR); Keun Suk Lee, Hanam-si (KR); Hyoun Jea Kim, Yongin-si (KR); Yu Kyong Shin, Yongin-si (KR); Hye Shin Ahn, Bucheon-si (KR); Kyung Tae Lee, Seoul (KR); and Ji Sun Shin, Seoul (KR)
Assigned to COSMAXBIO CO., LTD., Jecheon-si (KR)
Filed by COSMAXBIO CO., LTD., Jecheon-si (KR)
Filed on Mar. 9, 2021, as Appl. No. 17/196,513.
Application 17/196,513 is a continuation in part of application No. 16/772,471, abandoned, previously published as PCT/KR2018/004922, filed on Apr. 27, 2018.
Claims priority of application No. 10-2017-0175385 (KR), filed on Dec. 19, 2017.
Prior Publication US 2021/0196677 A1, Jul. 1, 2021
Int. Cl. A61K 31/366 (2006.01); A23L 33/105 (2016.01); A61K 8/49 (2006.01); A61K 8/9789 (2017.01); A61K 9/00 (2006.01); A61K 36/185 (2006.01); A61Q 19/00 (2006.01); A61Q 19/08 (2006.01)
CPC A61K 31/366 (2013.01) [A23L 33/105 (2016.08); A61K 8/498 (2013.01); A61K 8/9789 (2017.08); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 36/185 (2013.01); A61Q 19/004 (2013.01); A61Q 19/08 (2013.01); A61K 2236/333 (2013.01); A61K 2236/39 (2013.01); A61K 2236/53 (2013.01); A61K 2800/92 (2013.01)] 8 Claims
 
1. A method for preventing or improving UV-induced skin damage of a subject in need thereof, the method comprising: administering to the subject an effective amount of a composition containing hydrangenol represented by the following chemical formula 1 as an active ingredient:

OG Complex Work Unit Chemistry
wherein the hydrangenol prevents or improves UV-induced skin damage of the subject by accelerating proliferation of skin cells damaged by UV radiation, reducing production of MMP-1, and increasing production of procollagen and hyaluronic acid.