US 12,213,954 B2
Colchicine solution
Ioannis Psarrakis, Lavrion (GR); and Konstantinos Lioumis, Lavrion (GR)
Assigned to PHARMA-DATA RESEARCH AND DEVELOPMENT SINGLE MEMBER S.A., Lavrio (GR)
Appl. No. 18/681,394
Filed by PHARMA-DATA RESEARCH AND DEVELOPMENT SINGLE MEMBER S.A., Lavrio (GR)
PCT Filed Aug. 8, 2022, PCT No. PCT/EP2022/072274
§ 371(c)(1), (2) Date Feb. 5, 2024,
PCT Pub. No. WO2023/012374, PCT Pub. Date Feb. 9, 2023.
Claims priority of provisional application 63/262,070, filed on Oct. 4, 2021.
Claims priority of application No. 2028937 (NL), filed on Aug. 6, 2021.
Prior Publication US 2024/0277638 A1, Aug. 22, 2024
Int. Cl. A61K 31/165 (2006.01); A61K 9/08 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/14 (2017.01); A61K 47/36 (2006.01); A61K 47/38 (2006.01)
CPC A61K 31/165 (2013.01) [A61K 9/08 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/14 (2013.01); A61K 47/36 (2013.01); A61K 47/38 (2013.01)] 21 Claims
 
1. A buffered aqueous colchicine solution or suspension being free of benzyl alcohol, propylene glycol and thickener, comprising colchicine, a water miscible solvent and a preservative, wherein the solution or suspension comprises 0.02-1.0 w/v % colchicine, 2.5-15.0 w/v % glycerol and 0.05-1 w/v % preservative, the pH of the solution or suspension being 3.5-7.0.