US 12,213,838 B2
Temporally balanced multi-mode master imaging sequence for ultrasonic contrast imaging
Thanasis Loupas, Kirkland, WA (US); Paul Sheeran, Woodinville, WA (US); Charles Tremblay-Darveau, Seattle, WA (US); and Jeffry Earl Powers, Bainbridge Island, WA (US)
Assigned to KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Appl. No. 17/617,360
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
PCT Filed Jun. 4, 2020, PCT No. PCT/EP2020/065504
§ 371(c)(1), (2) Date Dec. 8, 2021,
PCT Pub. No. WO2020/249464, PCT Pub. Date Dec. 17, 2020.
Claims priority of provisional application 62/859,936, filed on Jun. 11, 2019.
Prior Publication US 2022/0218312 A1, Jul. 14, 2022
Int. Cl. A61B 8/08 (2006.01); A61B 8/00 (2006.01); A61B 8/06 (2006.01); A61B 8/14 (2006.01); G01S 7/52 (2006.01); G01S 15/89 (2006.01)
CPC A61B 8/5276 (2013.01) [A61B 8/06 (2013.01); A61B 8/14 (2013.01); A61B 8/463 (2013.01); A61B 8/5207 (2013.01); G01S 7/5202 (2013.01); G01S 7/52026 (2013.01); G01S 7/52039 (2013.01); G01S 15/8915 (2013.01)] 15 Claims
OG exemplary drawing
 
1. An ultrasound method for distinguishing non-perfused tissue from at least one of blood flow or blood perfusion comprising:
transmitting a sequence of ultrasound signals including a first complement and a second complement to a patient via a plurality of ultrasound transducer elements;
receiving a sequence of echo signals corresponding to the sequence of ultrasound signals;
combining a first selected set of echo signals to produce an Amplitude Modulated (AM) signal;
combining a second selected set of echo signals to produce an Amplitude Modulated Phase Inversion (AMPI) signal;
creating at least one image based on at least one of the AM signal or the AMPI signal;
displaying the at least one image;
wherein at least one of an order of at least one of the first selected set of echo signals or the second selected set of echo signals is temporally balanced by having echo signals of the first complement in the first selected set or the second selected set occur on each side of an echo signal of the second complement in the first selected set or the second selected set, or center times of the first selected set of echo signals or the second selected set of echo signals are temporally balanced by having center times of echo signals of the first complement in the first selected set or the second selected set evenly displaced around a center time of an echo signal of the second complement in the first selected set or the second selected set;
wherein a characteristic of each of the echo signals is set to be equal in each combining to produce the AM and AMPI signals.