US 12,213,797 B2
Apparatus for multimodal analysis of allergic reactions in skin tests and a hybrid method for multispectral imaging of allergic reactions in skin tests and its use for automatic evaluation of the results of these tests
Jacek Stepien, Warsaw (PL); Radoslaw Solan, Warsaw (PL); and Pawel Lukasiewicz, Warsaw (PL)
Assigned to MILTON ESSEX SA, Warsaw (PL)
Appl. No. 17/047,768
Filed by MILTON ESSEX SA, Warsaw (PL)
PCT Filed Apr. 23, 2019, PCT No. PCT/EP2019/060315
§ 371(c)(1), (2) Date Oct. 15, 2020,
PCT Pub. No. WO2019/211118, PCT Pub. Date Nov. 7, 2019.
Claims priority of application No. 425395 (PL), filed on Apr. 30, 2018.
Prior Publication US 2021/0169396 A1, Jun. 10, 2021
Int. Cl. A61B 5/00 (2006.01); A61B 5/01 (2006.01); A61B 5/026 (2006.01); G01B 11/25 (2006.01)
CPC A61B 5/411 (2013.01) [A61B 5/0064 (2013.01); A61B 5/0077 (2013.01); A61B 5/015 (2013.01); A61B 5/0261 (2013.01); A61B 5/445 (2013.01); A61B 2560/0223 (2013.01); A61B 2560/0406 (2013.01)] 4 Claims
OG exemplary drawing
 
1. A method for imaging allergic skin reactions during a Prick test or Patch test applied to a tested area of a patient's skin, comprising:
in the case that a Prick test is applied, recording a hyperthermic component of an allergic Type I reaction occurring at the tested area using a thermal imaging camera and also performing transdermal laser Doppler flowmetry at the tested area;
in the case that a Patch test is applied, recording a hyperthermic component of an allergic Type IV reaction occurring at the tested area by using a thermal imaging camera and also recording an optical component reflecting a topography of the tested area with identification of surface skin lesions via optical reflectometry using a 3D scanner, and
based on thermal imaging obtained either by the transdermal laser Doppler flowmetry or the optical reflectometry, developing an indication of the allergic reaction of the tested area.