US 12,213,770 B2
Portable device for quantitative measurement of tissue autoregulation and neurovascular coupling using EEG, metabolism, and blood flow diagnostics
Yama Akbari, Irvine, CA (US); Robert H. Wilson, Irvine, CA (US); Christian Crouzet, Irvine, CA (US); Thomas Milner, Irvine, CA (US); and Bernard Choi, Irvine, CA (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Filed by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Filed on Jul. 15, 2021, as Appl. No. 17/377,123.
Application 17/377,123 is a continuation in part of application No. 16/985,113, filed on Aug. 4, 2020, abandoned.
Application 16/985,113 is a continuation in part of application No. PCT/US2020/035440, filed on May 29, 2020.
Application 16/985,113 is a continuation in part of application No. 16/837,478, filed on Apr. 1, 2020, abandoned.
Claims priority of provisional application 63/032,491, filed on May 29, 2020.
Claims priority of provisional application 62/854,215, filed on May 29, 2019.
Claims priority of provisional application 62/827,668, filed on Apr. 1, 2019.
Prior Publication US 2021/0338092 A1, Nov. 4, 2021
Int. Cl. A61B 5/026 (2006.01); A61B 5/00 (2006.01); A61B 5/02 (2006.01); A61B 5/0205 (2006.01); A61B 5/145 (2006.01); A61B 5/1455 (2006.01); A61B 5/369 (2021.01); A61N 1/04 (2006.01); A61N 1/36 (2006.01); A61N 2/00 (2006.01); A61N 5/06 (2006.01)
CPC A61B 5/0261 (2013.01) [A61B 5/0075 (2013.01); A61B 5/14553 (2013.01); A61B 5/6801 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A non-invasive method of determining a depth-calibrated absolute value of cerebral metabolic rate of oxygen (CMRO2) using optical measurement of tissue perfusion, absorption, and scattering, the method comprising:
a. positioning one or more light sources and two or more detectors in proximity to a cerebral tissue of a subject;
b. emitting a coherent light signal from one or more of the light sources into the head, such that that one or more backscattered light signals are generated;
c. detecting one or more of the backscattered light signals via the two or more detectors;
d. determining a dynamic perfusion metric, a tissue absorption coefficient, and a tissue scattering coefficient from the detected signals;
e. determining a mean penetration depth of the detected signals, using the tissue absorption coefficient and tissue scattering coefficient; and
f. determining an absolute value of CMRO2 using the mean penetration depth, the dynamic perfusion metric, the tissue absorption coefficient, and the tissue scattering coefficient;
wherein absolute value of CMRO2 is depth-calibrated using the mean penetration depth, and
wherein the dynamic perfusion metric, the tissue absorption coefficient, and the tissue scattering coefficient provide all the information necessary to calculate the depth-calibrated absolute value of CMRO2.