US 12,213,464 B2
Single nucleotide polymorphisms and feeding efficiency in cattle
Graham Plastow, Edmonton (CA); and Mohammed Abo-Ismail, Edmonton (CA)
Assigned to The Governors of the University of Alberta, Edmonton (CA)
Appl. No. 16/757,505
Filed by The Governors of the University of Alberta, Edmonton (CA)
PCT Filed Oct. 19, 2018, PCT No. PCT/CA2018/051326
§ 371(c)(1), (2) Date Apr. 20, 2020,
PCT Pub. No. WO2019/075577, PCT Pub. Date Apr. 25, 2019.
Claims priority of provisional application 62/574,925, filed on Oct. 20, 2017.
Prior Publication US 2021/0195876 A1, Jul. 1, 2021
Int. Cl. C12Q 1/68 (2018.01); A01K 67/027 (2006.01); C12P 19/34 (2006.01); C12Q 1/6876 (2018.01)
CPC A01K 67/027 (2013.01) [C12Q 1/6876 (2013.01); A01K 2227/101 (2013.01); C12Q 2600/124 (2013.01); C12Q 2600/156 (2013.01)] 23 Claims
 
1. A method for producing meat from or breeding a Bos taurus animal having increased feed efficiency, the method comprising:
obtaining nucleic acid samples from members of a population of Bos taurus animals;
genotyping the samples to detect alleles of single nucleotide polymorphisms (SNPs) in a panel of SNPs for each member of the population, wherein the panel of SNPs comprises rs109382589, rs208660945, rs43702346, rs137601357, rs210072660, rs133057384, rs41821600, rs476872493, rs134264563, rs385640152, rs43020736, rs110216983, rs109930382, rs109558734, and rs209765899;
assigning a molecular breeding value to each animal in the population, wherein the molecular breeding value is calculated from allele substitution effects on at least one feed efficiency phenotype for each detected allele in the SNP panel for the animal, and wherein the at least one feed efficiency phenotype comprises Residual Feed Intake (RFI) and/or Residual Feed Intake adjusted for backfat (RFIf); and
producing meat from and/or breeding a Bos taurus animal from the population having a molecular breeding value in the top 16% of the population.