US 9,241,999 C1 (12,831st)
Method of producing physiological and therapeutic levels of nitric oxide through an oral delivery system
Nathan S. Bryan, Houston, TX (US); and Jose G. Rocca, Doral, FL (US)
Filed by Nathan S. Bryan, Houston, TX (US); and Jose G. Rocca, Doral, FL (US)
Assigned to NEOGENIS LABS, INC., Austin, TX (US)
Reexamination Request No. 90/015,001, Apr. 8, 2022.
Reexamination Certificate for Patent 9,241,999, issued Jan. 26, 2016, Appl. No. 13/588,211, Aug. 17, 2012.
Application 90/015,001 is a continuation in part of application No. 12/484,364, filed on Jun. 15, 2009, granted, now 8,298,589.
Claims priority of provisional application 61/524,539, filed on Aug. 17, 2011.
Ex Parte Reexamination Certificate issued on Jan. 29, 2025.
Int. Cl. A61K 33/00 (2006.01); A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 31/195 (2006.01); A61K 31/198 (2006.01); A61K 31/375 (2006.01); A61K 31/714 (2006.01); A61K 36/21 (2006.01); A61K 36/734 (2006.01); A61K 38/44 (2006.01); A61K 45/06 (2006.01)
CPC A61K 33/00 (2013.01) [A61K 9/0053 (2013.01); A61K 9/0056 (2013.01); A61K 9/20 (2013.01); A61K 9/2009 (2013.01); A61K 9/2013 (2013.01); A61K 31/195 (2013.01); A61K 31/198 (2013.01); A61K 31/375 (2013.01); A61K 31/714 (2013.01); A61K 36/21 (2013.01); A61K 36/734 (2013.01); A61K 38/44 (2013.01); A61K 45/06 (2013.01); C12Y 107/02001 (2013.01)]
OG exemplary drawing
AS A RESULT OF REEXAMINATION, IT HAS BEEN DETERMINED THAT:
Claims 1, 4 and 14 are determined to be patentable as amended.
Claims 2, 3, 5-13, and 15-27, dependent on an amended claim, are determined to be patentable.
New claims 28-32 are added and determined to be patentable.
1. A composition comprising:
about 1 mg to about 150 mg of a nitrite salt and
about 10 mg to about 10,000 mg of nitrite reductase,
wherein the composition is an oral composition [ in a single dosage form ] and wherein the composition comprises about 1,000 mg to about 10,000 mg of beet root in powder form;
[ wherein a range of nitrite: nitrate in the composition is 1:0.1-1.0.]
4. The composition of claim 1, wherein the composition further comprises a plant material of at least one of hawthorn berry , Schizandra, bilberry, green tea, pine bark, rhodiola, gingko, and artichoke and the plant material [ hawthorn berry ] comprises at least a portion of the nitrite reductase.
14. The composition of claim 1, wherein the composition is in a form of a lozenge, tablet, [ or ] wafer , powder, granules, cream, gel, emulsion, semisolid mixture, suspension, liquid, or heterogenic liquid.
28. [ A method of increasing levels of nitric oxide in an individual, the method comprising:
ingesting a composition only once or twice per day, the composition comprising:
1 mg to 150 mg of a nitrite salt and
10 mg to 10,000 mg of nitrite reductase,
wherein the composition is an oral composition in a single dosage form and wherein the composition comprises 1,000 mg to 10,000 mg of beet root in powder form.]
29. [ The method of claim 28, wherein the individual ingesting the composition is an adult human.]
30. [ The method of claim 28, wherein the composition is only ingested once per day.]
31. [ The method of claim 30, wherein the individual ingesting the composition is an adult human.]
32. [ A method of increasing levels of nitric oxide in an individual, the method comprising:
ingesting a composition, the composition comprising:
1 mg to 150 mg of a nitrite salt and
10 mg to 10,000 mg of nitrite reductase,
wherein the composition is an oral composition in a single dosage form and wherein the composition comprises 1,000 mg to 10,000 mg of beet root in powder form;
wherein the individual ingesting the composition has a bodyweight between 70 and 80 kilograms.]