US 11,887,710 B2
Precision-based immuno-molecular augmentation (PBIMA) computerized system, method, and therapeutic vaccine
Shamsuddin Sultan Khan, Dhaka zila (BD); John A. Catanzaro, Rockwall, TX (US); and Anton Yuryev, Gaithersburg, MD (US)
Assigned to Neo7Logix, LLC
Filed by Neo7Logix, LLC, Dallas, TX (US)
Filed on Sep. 14, 2022, as Appl. No. 17/944,335.
Application 17/944,335 is a continuation of application No. PCT/US2021/022858, filed on Mar. 17, 2021.
Claims priority of provisional application 63/029,633, filed on May 25, 2020.
Claims priority of provisional application 62/992,227, filed on Mar. 20, 2020.
Prior Publication US 2023/0146516 A1, May 11, 2023
Int. Cl. G16H 10/60 (2018.01); G16H 10/40 (2018.01); G16B 50/20 (2019.01); G16B 20/00 (2019.01)
CPC G16H 10/60 (2018.01) [G16B 20/00 (2019.02); G16B 50/20 (2019.02); G16H 10/40 (2018.01)] 19 Claims
OG exemplary drawing
 
1. A precision-based immunomolecular augmentation (PBIMA) computerized method for designing and treating a patient with a customized therapeutic peptides or peptide vaccine, comprising:
receiving a data input, by a cloud-based system, of a patient data comprising one or more of: a patient transcriptomics data, and a patient urine proteomics data;
computing a precision data output, by the cloud-based system, of a vaccine composition comprising a plurality of ranked peptide sequences encoding self-antigens and/or neo-antigens for a CD4+/CD8+ natural killer (NK) cell modulation specific to a patient's profile, and able to elicit an effective therapeutic response against a patient disease;
computing a CRISPR prime editing and an intracellular multi-core processing on the vaccine composition to produce a DNA-RNA and epigenetic modulation plurality of immunopeptide sequences;
conducting an immunopeptide synthesis and manufacturing of the vaccine composition;
conducting the delivery of the vaccine composition to a patient's clinician or institution, and administrating the vaccine composition to the patient; and
wherein the patient has been diagnosed with, and/or is genetically predisposed to one or more diseases comprising: a cancer, an autoimmune disease, a neurodegenerative disease, and/or a pathogenic infectious disease.