US 11,885,818 B2
Reagent for mass spectrometry
Dieter Heindl, Munich (DE); Hans-Peter Josel, Weilheim (DE); Uwe Kobold, Weilheim (DE); Christoph Seidel, Weilheim (DE); Martin Rempt, Penzberg (DE); Andreas Leinenbach, Oberhausen (DE); Giuseppe Prencipe, Penzberg (DE); Silvia Baecher, Munich (DE); Simon Ferdinand Loibl, Wolfratshausen (DE); Anna-Skrollan Geiermann, Munich (DE); Jelena Milic, Penzberg (DE); and Nicole Pirkl, Penzberg (DE)
Assigned to Roche Diagnostics Operations, Inc., Indianapolis, IN (US)
Filed by Roche Diagnostics Operations, Inc., Indianapolis, IN (US)
Filed on Jan. 21, 2021, as Appl. No. 17/155,054.
Application 17/155,054 is a continuation of application No. PCT/EP2019/069730, filed on Jul. 23, 2019.
Claims priority of application No. 18185355 (EP), filed on Jul. 24, 2018.
Prior Publication US 2021/0140983 A1, May 13, 2021
Int. Cl. C07D 401/06 (2006.01); C07D 413/06 (2006.01); G01N 33/74 (2006.01); G01N 33/58 (2006.01); C07J 43/00 (2006.01)
CPC G01N 33/743 (2013.01) [C07D 401/06 (2013.01); C07D 413/06 (2013.01); C07J 43/003 (2013.01); G01N 33/58 (2013.01); G01N 2560/00 (2013.01)] 7 Claims
 
1. A compound of formula A:
X-L1-Z-L2-Y
wherein
X is a reactive unit, which is capable of forming a covalent bond with an analyte molecule,
L1 and L2 are independently of each other substituted or unsubstituted linker
Y is a neutral loss unit,
Z is a charged unit comprising at least one permanently charged moiety,
including any salt thereof,
wherein the reactive unit X is H2N—NH—, the neutral loss unit Y is triazole or tetrazole, and the charge unit Z comprises a piperidine unit, or
wherein the compound is selected from the group consisting of:

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry