US 11,885,809 B2
Methods and devices for determining a guest structure on a host structure
Iddo Heller, Amsterdam (NL); Anna Elisabeth Christina Meijering, Amsterdam (NL); Gijs Jan Lodewijk Wuite, Amsterdam (NL); Erwin Johannes Gerard Peterman, Amsterdam (NL); and Andreas Sebastian Biebricher, Amsterdam (NL)
Assigned to LUMICKS DSM HOLDING B.V.
Filed by LUMICKS DSM HOLDING B.V., Amsterdam (NL)
Filed on Nov. 2, 2021, as Appl. No. 17/517,381.
Application 17/517,381 is a continuation of application No. 16/967,111, granted, now 11,187,656, previously published as PCT/NL2019/050071, filed on Feb. 5, 2019.
Claims priority of application No. 2020377 (NL), filed on Feb. 5, 2018.
Prior Publication US 2022/0057326 A1, Feb. 24, 2022
Int. Cl. G01N 33/58 (2006.01); G16B 15/00 (2019.01); G01N 21/64 (2006.01); G06V 20/69 (2022.01)
CPC G01N 33/58 (2013.01) [G01N 21/6402 (2013.01); G01N 21/6428 (2013.01); G01N 21/6458 (2013.01); G06V 20/693 (2022.01); G16B 15/00 (2019.02); G01N 2201/0633 (2013.01); G01N 2201/06113 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for determining a length of a protein filament residing on a DNA-molecule, the method comprising steps of:
receiving light from the DNA-molecule hosting one or more optically active entities at at least one part of the DNA molecule not hosting the protein filament using a light-sensitive system, wherein the optically active entities cause light emission from said at least one part, and
the light-sensitive system outputting a signal based on the received light, and
determining a light value based on the output signal, the light value indicating an amount of light from the host structure being incident on the light-sensitive system, and
determining on the basis of the light value the length of the protein filament.