	US 11,884,926 B2
	Campaign-ready series of recombinant adeno-associated virus (rAAV) complementing plasmids
Terence Flotte, Holden, MA (US); Qiushi Tang, Worcester, MA (US); Allison Keeler-Klunk, Sutton, MA (US); and Qin Su, Westborough, MA (US)
Assigned to University of Massachusetts, Boston, MA (US)
Appl. No. 16/966,504
Filed by University of Massachusetts, Boston, MA (US)
PCT Filed Feb. 1, 2019, PCT No. PCT/US2019/016310 § 371(c)(1), (2) Date Jul. 31, 2020, PCT Pub. No. WO2019/152816, PCT Pub. Date Aug. 8, 2019.
Claims priority of provisional application 62/625,644, filed on Feb. 2, 2018.
Prior Publication US 2021/0047650 A1, Feb. 18, 2021
Int. Cl. C12N 15/70 (2006.01); C12N 7/00 (2006.01)

CPC C12N 15/70 (2013.01) [C12N 7/00 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14151 (2013.01); C12N 2750/14171 (2013.01)]

18 Claims

1. A recombinant adeno-associated virus (rAAV) production system comprising:

(i) a first vector comprising the nucleic acid sequence set forth in any one of SEQ ID NOs: 1-9;

and,

(ii) a second vector comprising one or more nucleic acids encoding an expression cassette comprising a transgene flanked by adeno-associated virus inverted terminal repeat (ITR) sequences.