US 11,884,852 B2
Highly sensitive methods for detecting biomolecules based on multiple quantum dots
Bong Hyun Jun, Seoul (KR); Sung Wook Yoon, Anyang-si (KR); Yoon Sik Lee, Anyang-si (KR); Dong Ok Choi, Yongin-si (KR); Xuan Hung Pham, Seoul (KR); Tae Han Kim, Goyang-si (KR); and Jung Won Kim, Hwaseong-si (KR)
Assigned to BIOSQUARE INC., Seongnam-si (KR); and KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORP, Seoul (KR)
Appl. No. 16/650,794
Filed by BIOSQUARE INC., Seongnam-si (KR); and KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORP, Seoul (KR)
PCT Filed Sep. 28, 2018, PCT No. PCT/KR2018/011553
§ 371(c)(1), (2) Date Mar. 25, 2020,
PCT Pub. No. WO2019/066567, PCT Pub. Date Apr. 4, 2019.
Claims priority of application No. 10-2017-0126515 (KR), filed on Sep. 28, 2017.
Prior Publication US 2021/0380876 A1, Dec. 9, 2021
Int. Cl. C09K 11/02 (2006.01); C09K 11/88 (2006.01); G01N 33/58 (2006.01)
CPC C09K 11/025 (2013.01) [C09K 11/883 (2013.01); G01N 33/588 (2013.01)] 7 Claims
OG exemplary drawing
 
1. Quantum dot-doped nanoparticles, each of the quantum dot-doped nanoparticles comprises:
a core particle, wherein the core particle is a polymer or inorganic material;
a quantum dot-embedded layer, wherein the quantum dot-embedded layer consists of first multiple quantum dots bound to the outer surface of the core particle and the first multiple quantum dots surround the entire surface of the core particle;
a silica/quantum dot composite shell, wherein the silica/quantum dot composite shell comprises second multiple quantum dots and a silica and surrounds the quantum dot-embedded layer;
a first material comprising functional groups at opposite ends of the first material; and
a second material comprising functional groups at opposite ends of the second material,
wherein,
the first material is present between the core particle and the first multiple quantum dots, and
each of the first multiple quantum dots is bonded to one of the functional groups of the first material and the outer surface of the core particle is bonded to another of the functional groups of the first material such that each of the first multiple quantum dots is covalently bonded to the core particle.