	US 11,884,845 B2
	Body fluid resistant tissue adhesives
Xuanhe Zhao, Allston, MA (US); Hyunwoo Yuk, Cambridge, MA (US); Xinyu Mao, Cambridge, MA (US); and Christoph Nabzdyk, Rochester, MN (US)
Assigned to MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US); and MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, Rochester, MN (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US); and Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Filed on Dec. 3, 2020, as Appl. No. 17/110,841.
Claims priority of provisional application 62/942,874, filed on Dec. 3, 2019.
Prior Publication US 2021/0163797 A1, Jun. 3, 2021
Int. Cl. C09J 105/08 (2006.01); C09J 133/02 (2006.01); A61L 24/00 (2006.01); C09J 11/06 (2006.01); C09J 9/00 (2006.01); C09J 151/00 (2006.01)

CPC C09J 105/08 (2013.01) [A61L 24/0042 (2013.01); A61L 24/0094 (2013.01); C09J 9/00 (2013.01); C09J 11/06 (2013.01); C09J 133/02 (2013.01); C09J 151/003 (2013.01); A61L 2400/04 (2013.01); C09J 2483/00 (2013.01)]

16 Claims

1. An adhesive material for adhering one or more fluid covered surfaces comprising:

a hydrophobic matrix; and

a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix, the bioadhesive microparticles comprising:

(i) one or more hydrophilic polymers or copolymers;

(ii) one or more amine coupling groups, and

(iii) one or more cross linkers,

the hydrophobic matrix forming a protective matrix around the dispersed bioadhesive microparticles that protects the bioadhesive microparticles from the fluid, wherein disposing the adhesive material directly on the fluid covered surface and applying pressure to the adhesive material causes (a) the hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.