US 11,884,826 B2
Protected dye-labeled reagents
Lubomir Sebo, Redwood City, CA (US); Honey Osuna, San Francisco, CA (US); Stephen Yue, Eugene, OR (US); and Yuri Lapin, Newark, CA (US)
Assigned to Pacific Biosciences of California, Inc., Menlo Park, CA (US)
Filed by Pacific Biosciences of California, Inc., Menlo Park, CA (US)
Filed on Dec. 20, 2021, as Appl. No. 17/556,800.
Application 17/556,800 is a continuation of application No. 16/779,439, filed on Jan. 31, 2020, granted, now 11,203,689.
Application 16/779,439 is a continuation of application No. 15/357,965, filed on Nov. 21, 2016, granted, now 10,669,299, issued on Jun. 2, 2020.
Claims priority of provisional application 62/258,415, filed on Nov. 20, 2015.
Prior Publication US 2022/0396702 A1, Dec. 15, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C09B 69/10 (2006.01); C07H 19/10 (2006.01); C07H 19/207 (2006.01); C07D 495/04 (2006.01); C12Q 1/6869 (2018.01); G01N 21/64 (2006.01)
CPC C09B 69/105 (2013.01) [C07D 495/04 (2013.01); C07H 19/10 (2013.01); C07H 19/207 (2013.01); C12Q 1/6869 (2013.01); G01N 21/6428 (2013.01); G01N 2021/6439 (2013.01)] 31 Claims
 
1. A dye-labeled compound of structural formula (IIIG):

OG Complex Work Unit Chemistry
wherein
each L′ is independently a dye compound linker element;
each S is independently a shield element, wherein the shield element does not comprise a protein;
each Dye is independently either an acceptor dye or a donor dye;
each B″ is independently a terminal coupling element;
each p is independently 0 or 1; and
each r″ is independently an integer from 0 to 8;
s is an integer from 1 to 6; and
t is 0 or 1;
wherein the compound comprises at least one shield element, at least one acceptor dye, and at least one donor dye; and
wherein the terminal coupling element comprises a first reactive functional group or a residue derived from a first reactive functional group.