	US 11,884,734 B2
	Anti-MET antibodies and methods of use thereof
Yan Yang, Hamden, CT (US); Sreekala Mandiyan, Bloomfield, NJ (US); Brett Robinson, Preston, CT (US); Lida Kimmel, Chester, CT (US); Yaron Hadari, Harrison, NY (US); Timothy David Jones, Babraham (GB); Francis Joseph Carr, Balmedie (GB); Robert George Edward Holgate, Royston (GB); and Richard Weldon, Wädenswil (CH)
Assigned to Celldex Therapeutics, Inc., Hampton, NJ (US)
Filed by Celldex Therapeutics, Inc., Hampton, NJ (US)
Filed on Sep. 15, 2020, as Appl. No. 17/021,423.
Application 17/021,423 is a division of application No. 15/558,306, abandoned, previously published as PCT/US2016/022464, filed on Mar. 15, 2016.
Claims priority of provisional application 62/149,465, filed on Apr. 17, 2015.
Claims priority of provisional application 62/133,789, filed on Mar. 16, 2015.
Prior Publication US 2021/0130476 A1, May 6, 2021
Int. Cl. C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); C07K 16/30 (2006.01); A61K 39/00 (2006.01)

CPC C07K 16/2863 (2013.01) [A61K 39/39558 (2013.01); A61K 45/06 (2013.01); C07K 16/30 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/52 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/70 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01)]

16 Claims

1. A monoclonal antibody or antigen-binding fragment thereof that binds to human MET, wherein the antibody or antigen-binding fragment thereof comprises:

a. a light chain variable region (“VL”) comprising:

i. a VL CDR1 comprising the amino acid sequence of SEQ ID NO: 13;

ii. a VL CDR2 comprising the amino acid sequence of SEQ ID NO: 14; and

iii. a VL CDR3 comprising the amino acid sequence of SEQ ID NO: 15; and

b. a heavy chain variable region (“VH”) comprising:

i. a VH CDR1 comprising the amino acid sequence of SEQ ID NO: 16;

ii. a VH CDR2 comprising the amino acid sequence of SEQ ID NO: 17; and

iii. a VH CDR3 comprising the amino acid sequence of SEQ ID NO: 18.