	US 11,884,724 B2
	Anti-PD-L1 antibodies and uses thereof
Horacio G. Nastri, Needham, MA (US); Christel Iffland, Cambridge, MA (US); Olivier Leger, Saint-Sixt (FR); Qi An, Nashua, NH (US); Mark Cartwright, West Newton, MA (US); and Sean D. McKenna, Duxbury, MA (US)
Assigned to Merck Patent GmbH, Darmstadt (DE)
Filed by Merck Patent GmbH, Darmstadt (DE)
Filed on Aug. 4, 2020, as Appl. No. 16/984,365.
Application 15/454,939 is a division of application No. 14/360,775, granted, now 9,624,298, issued on Apr. 18, 2017, previously published as PCT/EP2012/004822, filed on Nov. 21, 2012.
Application 16/984,365 is a continuation of application No. 15/454,939, filed on Mar. 9, 2017, granted, now 10,759,856, issued on Sep. 1, 2020.
Claims priority of provisional application 61/563,903, filed on Nov. 28, 2011.
Prior Publication US 2021/0054073 A1, Feb. 25, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/28 (2006.01); A61K 45/06 (2006.01); A61K 31/555 (2006.01); A61K 39/395 (2006.01); A61K 31/675 (2006.01); A61K 31/7068 (2006.01); A61K 39/00 (2006.01); A61K 31/282 (2006.01); A61K 31/513 (2006.01); A61K 31/519 (2006.01)

CPC C07K 16/2803 (2013.01) [A61K 31/282 (2013.01); A61K 31/513 (2013.01); A61K 31/519 (2013.01); A61K 31/555 (2013.01); A61K 31/675 (2013.01); A61K 31/7068 (2013.01); A61K 39/001102 (2018.08); A61K 39/3955 (2013.01); A61K 39/39558 (2013.01); A61K 39/39591 (2013.01); A61K 45/06 (2013.01); C07K 16/2827 (2013.01); A61K 2039/505 (2013.01); C07K 2317/34 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/73 (2013.01); C07K 2317/732 (2013.01); C07K 2317/92 (2013.01)]

14 Claims

1. An isolated anti-PD-L1 antibody or antigen binding fragment thereof comprising:

(a) a heavy chain variable region; and

(b) a light chain variable region

comprising HVR-L1, HVR-L2 and HVR-L3 sequences,

wherein:

(i) the HVR-L1 sequence is TGTX₇X₈DVGX₉YNYVS (SEQ ID NO: 8); and

(ii) the HVR-L3 sequence is SSX₁₃TX₁₄X₁₅X₁₆X₁₇RV (SEQ ID NO: 10); and

wherein X₇is N or S; X₈is T, R or S; X₉is A or G; X₁₃is F or Y; X₁₄is N or S; X₁₅is R, T or S; X₁₆is G or S; and X₁₇is I or T.