US 11,884,708 B2
Stapled peptide inhibitors of nemo as potential anti-inflammatory and anti-cancer drugs
Fabrice Agou, Paris (FR); Alix Boucharlat, Paris (FR); Yves-Marie Coic, Meudon (FR); and Françoise Baleux, Paris (FR)
Assigned to INSTITUT PASTEUR, Paris (FR)
Filed by INSTITUT PASTEUR, Paris (FR)
Filed on Sep. 28, 2021, as Appl. No. 17/487,904.
Application 17/487,904 is a continuation of application No. 15/776,481, granted, now 11,149,070, previously published as PCT/EP2016/082390, filed on Dec. 22, 2016.
Claims priority of application No. 15307137 (EP), filed on Dec. 23, 2015.
Prior Publication US 2022/0025002 A1, Jan. 27, 2022
Int. Cl. C07K 14/47 (2006.01); A61K 38/00 (2006.01)
CPC C07K 14/4702 (2013.01) [A61K 38/00 (2013.01); C07K 2319/03 (2013.01)] 15 Claims
 
1. A peptide, comprising an amino sequence (I) which is at least 60% identical to the amino acid sequence SEQ ID NO: 1, and further comprising at least one macrocycle-forming linker connecting a first amino acid to a second amino acid of said sequence (I),
wherein the sequence (I) consists of:
 
 (SEQ ID NO: 2)
 
 LKX1QAX2X3YK X4RFX5X6X7R X8ARX9K,
in which:
X1 is A;
X2 is a cross-linked amino acid;
X3 is I;
X4 is A;
X5 is a cross-linked amino acid;
X6 is A;
X7 is E;
X8 is H or Q; and
X9 is E;
providing that X2 and X5 are cross-linked by the macrocycle-forming linker.