US 11,884,685 B2
Rhenium complexes and methods of use for treating cancer
Arthur Paden King, Rockville, MD (US); Sierra C. Marker, Rockville, MD (US); Robert Swanda, Windsor, NY (US); Shu-Bing Qian, Ithaca, NY (US); and Justin J. Wilson, Ithaca, NY (US)
Assigned to CORNELL UNIVERSITY, Ithaca, NY (US)
Appl. No. 17/267,687
Filed by CORNELL UNIVERSITY, Ithaca, NY (US)
PCT Filed Aug. 16, 2019, PCT No. PCT/US2019/046732
§ 371(c)(1), (2) Date Feb. 10, 2021,
PCT Pub. No. WO2020/037166, PCT Pub. Date Feb. 20, 2020.
Claims priority of provisional application 62/765,059, filed on Aug. 16, 2018.
Prior Publication US 2021/0317151 A1, Oct. 14, 2021
Int. Cl. C07F 13/00 (2006.01); A61P 35/00 (2006.01)
CPC C07F 13/00 (2013.01) [A61P 35/00 (2018.01)] 22 Claims
OG exemplary drawing
 
1. A composition comprising a rhenium(I) complex having the following structure:

OG Complex Work Unit Chemistry
wherein
Re represents a rhenium ion having a +1 charge;

OG Complex Work Unit Chemistry
represents an uncharged bidentate ligand of one of the following structures

OG Complex Work Unit Chemistry
 wherein R1, R2, R3, R4, R5, R6, R7, R8, R1a, R2a, R3a, R4a, R5a, R6a, R7a, and R8a are each independently selected from the group consisting of hydrogen atoms; hydrocarbon groups (R′) containing 1-6 carbon atoms; —ORa groups; —C(O)ORa groups; —OC(O)Ra groups; —C(O)Ra groups; and halogen atoms, wherein said hydrocarbon groups (R′) optionally include one or more heteroatoms selected from oxygen, nitrogen, and sulfur, and Ra is independently selected from hydrogen atoms and hydrocarbon groups (R′); and
L1 is an isonitrile ligand of the formula CN-R wherein R is an isonitrile ligand having the following structure:

OG Complex Work Unit Chemistry
wherein R1d and R5d are hydrogen; and R2d, R3d, and R4d are independently selected from hydrogen atoms, hydrocarbon groups (R′) containing 1-6 carbon atoms, —OR″ groups, —C(O)OR″ groups, —OC(O)R″ groups, —C(O)R″ groups, —NR″2 groups, —C(O)NR″2 groups, —NR″C(O)R″ groups, halogen atoms, —CN groups, and nitro groups; wherein the hydrocarbon groups (R′) optionally include one or more heteroatoms selected from oxygen, nitrogen, and sulfur; and R″ is independently selected from hydrogen atoms and hydrocarbon groups (R′);
L2, L3, and L4 are each independently CO; and
X31 represents a non-coordinating monovalent anion.