US 11,884,673 B2
Modulators of ion channel receptors and uses thereof
Belinda Huff, Thebarton (AU); Courtney Hollis, Mitchell Park (AU); Hamish Toop, Thebarton (AU); Nathan Kuchel, Cumberland Park (AU); Lorna Helen Mitchell, Thebarton (AU); and Rajinder Singh, Torrensville (AU)
Assigned to BIONOMICS LIMITED, Eastwood (AU)
Filed by BIONOMICS LIMITED, Thebarton (AU)
Filed on Apr. 20, 2022, as Appl. No. 17/724,601.
Application 17/724,601 is a continuation of application No. 17/056,248, granted, now 11,384,085, previously published as PCT/AU2019/050472, filed on May 17, 2019.
Claims priority of application No. 2018901729 (AU), filed on May 17, 2018; and application No. 2018903047 (AU), filed on Aug. 20, 2018.
Prior Publication US 2022/0251099 A1, Aug. 11, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 487/04 (2006.01); C07D 209/24 (2006.01); C07D 213/64 (2006.01); C07D 471/04 (2006.01)
CPC C07D 487/04 (2013.01) [C07D 209/24 (2013.01); C07D 213/64 (2013.01); C07D 471/04 (2013.01)] 16 Claims
 
1. A compound of formula (I)

OG Complex Work Unit Chemistry
or a salt, stereoisomer, solvate or prodrug thereof,
wherein
R is an optionally substituted aryl, optionally substituted heterocycyl or optionally substituted heteroaryl;
R1 is H or an optionally substituted C1-C4 alkyl;
R2, R3, R4 and R5 are independently H or a C1-C4 alkyl or R2 and R3, or R4 and R5 together form a cycloalkyl ring;
Y is selected from

OG Complex Work Unit Chemistry
X is CH or N; and
Z is F or CF3.