US 11,884,662 B2
N-1 branched cycloalkyl substituted imidazo[4,5-c]quinoline compounds, compositions, and methods
George W. Griesgraber, Eagan, MN (US); Hannah C. Cohen, St. Paul, MN (US); and Jana Ninkovic, St. Paul, MN (US)
Assigned to 3M Innovative Properties Company, St. Paul, MN (US)
Appl. No. 17/250,073
Filed by 3M INNOVATIVE PROPERTIES COMPANY, St. Paul, MN (US)
PCT Filed May 23, 2019, PCT No. PCT/IB2019/054273
§ 371(c)(1), (2) Date Nov. 19, 2020,
PCT Pub. No. WO2019/224765, PCT Pub. Date Nov. 28, 2019.
Claims priority of provisional application 62/675,980, filed on May 24, 2018.
Prior Publication US 2021/0317116 A1, Oct. 14, 2021
Int. Cl. C07D 471/04 (2006.01); A61P 37/02 (2006.01); A61K 31/4745 (2006.01)
CPC C07D 471/04 (2013.01) [A61K 31/4745 (2013.01); A61P 37/02 (2018.01)] 15 Claims
 
1. A compound of Formula (II), or salt thereof:

OG Complex Work Unit Chemistry
wherein:
n is an integer of 0 or 1;
R is selected from the group consisting of halogen, hydroxy, alkyl, alkoxy, and —C(O)—O— alkyl;
R1 is alkyl;
R2 is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, n-butyl, —CH2OCH3, —CH2OCH2CH3, and —CH2CH2OCH3; and
Z is a bond, —CH2—, —CH2CH2—, —CH2OCH2—, —CH2CH2CH2—, —CH2CH2CH2CH2—, or —C═C—.