CPC C07D 413/06 (2013.01) [A61K 31/451 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/495 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); C07D 207/16 (2013.01); C07D 211/26 (2013.01); C07D 211/34 (2013.01); C07D 211/56 (2013.01); C07D 211/62 (2013.01); C07D 211/70 (2013.01); C07D 241/04 (2013.01); C07D 295/135 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 403/06 (2013.01); C07D 405/06 (2013.01); C07D 417/04 (2013.01)] | 15 Claims |
1. A pharmaceutical composition comprising a compound of formula (Ic)
or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient,
wherein
X and Y are each N;
Z is CH;
Q is CH or N;
R1 is selected from hydrogen, C1-8 alkyl, C1-8 haloalkyl, and halogen;
each R2 is a member selected from the group consisting of C1-8 alkyl, C1-8 haloalkyl, halogen and —CN;
R4 is hydrogen or methyl;
R6 is absent or is a member selected from the group consisting of H, —OH, C1-8 alkyl, C1-8 hydroxyalkyl, C1-4 alkoxy-C1-4 alkyl, —C(O)NRaRb, —CO2H, —C(O)ORa, —C(O)Ra, and —SO2Ra;
R7 is absent or is selected from the group consisting of H, C1-8 alkyl and C1-8 haloalkyl;
each Ra and Rb are independently selected from the group consisting of hydrogen, C1-8 alkyl, C1-8 hydroxyalkyl, C1-8 haloalkyl, and C1-8 alkoxy; and
the subscript n is 1.
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