US 11,884,446 B2
Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus
John T. Felts, Alameda, CA (US); Thomas E. Fisk, Green Valley, AZ (US); Robert S. Abrams, Albany, NY (US); John Ferguson, Auburn, AL (US); Jonathan R. Freedman, Auburn, AL (US); Robert J. Pangborn, Harbor Springs, MI (US); Peter J. Sagona, Pottstown, PA (US); and Christopher Weikart, Auburn, AL (US)
Assigned to SIO2 Medical Products, Inc., Auburn, AL (US)
Filed by SiO2 Medical Products, Inc., Auburn, AL (US)
Filed on Nov. 16, 2022, as Appl. No. 17/988,450.
Application 16/226,463 is a division of application No. 14/357,418, granted, now 10,189,603, issued on Jan. 29, 2019, previously published as PCT/US2012/064489, filed on Nov. 9, 2012.
Application 17/988,450 is a continuation of application No. 17/484,944, filed on Sep. 24, 2021, granted, now 11,724,860.
Application 17/484,944 is a continuation of application No. 16/806,589, filed on Mar. 2, 2020, granted, now 11,148,856, issued on Oct. 19, 2021.
Application 16/806,589 is a continuation of application No. 16/226,463, filed on Dec. 19, 2018, granted, now 10,577,154, issued on Mar. 3, 2020.
Claims priority of provisional application 61/645,003, filed on May 9, 2012.
Claims priority of provisional application 61/636,377, filed on Apr. 20, 2012.
Claims priority of provisional application 61/558,885, filed on Nov. 11, 2011.
Prior Publication US 2023/0150727 A1, May 18, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. B65D 25/14 (2006.01); C23C 16/04 (2006.01); C23C 16/507 (2006.01); A61M 5/31 (2006.01); C23C 16/30 (2006.01); C23C 16/36 (2006.01); C23C 16/40 (2006.01); A61J 1/05 (2006.01); B65D 25/04 (2006.01)
CPC B65D 25/04 (2013.01) [A61M 5/3129 (2013.01); C23C 16/045 (2013.01); C23C 16/30 (2013.01); C23C 16/36 (2013.01); C23C 16/401 (2013.01); C23C 16/507 (2013.01); A61J 1/05 (2013.01); A61M 2005/3109 (2013.01); A61M 2005/3131 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A prefilled syringe comprising:
a syringe barrel having a lumen defined at least in part by a thermoplastic wall having an interior surface facing the lumen and an outer surface;
a lubricity coating of SiwOxCy, in which w is 1, x is from about 0.5 to about 2.4, and y is from about 0.6 to about 3, the lubricity coating having an inner surface facing the lumen and an outer surface facing the interior surface of the thermoplastic wall, the lubricity coating having a lower frictional resistance than an uncoated surface of the thermoplastic wall;
a fluid composition contained in the lumen, the fluid composition comprising a botulinum toxin and having a pH between 4 and 10,
a plunger tip positioned in the lumen and being slidable along the interior surface of the wall; and
a cap or needle shield at a distal end of the syringe barrel;
wherein the shelf life of the prefilled syringe is more than six months at a storage temperature of 4° C.