US 11,883,821 B2
Fluidic device for the detection, capture, or removal of a disease material
Sinead E. Miller, Houston, TX (US); Charleson S. Bell, Nashville, TN (US); Todd D. Giorgio, Nashville, TN (US); and Andrew L. Cook, Antioch, TN (US)
Assigned to Vanderbilt University, Nashville, TN (US)
Filed by Vanderbilt University, Nashville, TN (US)
Filed on Sep. 1, 2021, as Appl. No. 17/464,103.
Application 17/464,103 is a continuation of application No. 16/315,732, granted, now 11,154,861, previously published as PCT/US2017/041038, filed on Jul. 7, 2017.
Claims priority of provisional application 62/478,904, filed on Mar. 30, 2017.
Claims priority of provisional application 62/454,235, filed on Feb. 3, 2017.
Claims priority of provisional application 62/407,767, filed on Oct. 13, 2016.
Claims priority of provisional application 62/359,322, filed on Jul. 7, 2016.
Prior Publication US 2022/0134341 A1, May 5, 2022
Int. Cl. B01L 3/00 (2006.01); A61K 38/12 (2006.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01); G01N 33/48 (2006.01); A61K 38/14 (2006.01); A61M 5/165 (2006.01)
CPC B01L 3/502753 (2013.01) [A61K 38/12 (2013.01); A61K 38/14 (2013.01); A61M 5/165 (2013.01); B01L 3/502715 (2013.01); B01L 3/502776 (2013.01); G01N 33/48 (2013.01); G01N 33/53 (2013.01); G01N 33/543 (2013.01); B01L 2300/0861 (2013.01); B01L 2300/16 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for capture of a disease material from a biological fluid,
the method comprising:
introducing the biological fluid into a fluidic device, wherein the fluidic device comprises at least one inlet, at least one outlet, and a multidirectional channel between the at least one inlet and the at least one outlet;
flowing the biological fluid through the fluidic device to expose the disease material to a disease material-targeting ligand functionalized along at least a portion of an inner wall of the multidirectional channel within the fluidic device;
capturing the disease material with the disease material-targeting ligand, thereby removing the disease material from the biological fluid;
removing the disease material from the biological fluid to produce treated biological fluid; and
returning the treated biological fluid to a patient.